ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Prostaglandin D2 receptor antagonists in allergic disorders: safety, efficacy, and future perspectives. Authors: Marone G1,2, Galdiero MR3,4, Pecoraro A3,4, Pucino V5, Criscuolo G3,4, Triassi M1, Varricchi G3,4. 1 a Department of Public Health , University of Naples Federico II , Naples , Italy. 2 b Monaldi Hospital Pharmacy , Naples , Italy. 3 c Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI) , University of Naples Federico II , Naples , Italy. 4 d WAO Center of Excellence , Naples , Italy. 5 e William Harvey Research Institute, Barts and The London School of Medicine &Dentistry , Queen Mary University of London , London , UK. Abstract: Prostaglandin D2 (PGD2) is a major cyclooxygenase mediator that is synthesized by activated human mast cells and other immune cells. The biological effects of PGD2 are mediated by D-prostanoid (DP1), DP2 (CRTH2) and thromboxane prostanoid (TP) receptors that are expressed on s

Reacciones adversas a aditivos Dr. Luis Carlos Santamaría (Diciembre de 2018)

Thyroid Autoimmunity and Autoimmunity in Chronic Spontaneous Urticaria Linked to Disease Severity, Therapeutic Response, and Time to Remission in Patients with Chronic Spontaneous Urticaria. Authors:  Chanprapaph K, Iamsumang W, Wattanakrai P, Vachiramon V .  Division of Dermatology, Department of Internal Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Abstract:  BACKGROUND: Chronic spontaneous urticaria (CSU) is autoimmune in nature and associated with thyroid autoimmunity (TA), but evidence on autoimmunity in relation to CSU progression and prognosis is limited. We evaluated whether TA and autoimmunity in CSU are correlated with disease severity, therapeutic response, and time to remission and establish an association between CSU characteristics linked to thyroid autoantibody. METHODS: Medical records of patients diagnosed with urticaria attending outpatient dermatology clinic at a university-based hospital from 2013 to 2017 were retrospectivel

Unproven Diagnostic Tests for Adverse Reactions to Foods Authors: John M. Kelso , Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, Calif. Abstract: Patients often seek opinions from allergists regarding unconventional testing for adverse reactions to foods. These tests include flow cytometry to measure the change in white blood cell volumes after incubation with foods, measurement of serum IgG or IgG4 antibodies directed against foods, intradermal provocation-neutralization with food allergens, hair analysis, electrodermal testing, and applied kinesiology. In some cases, although the laboratory methods may be valid, there are no studies showing correlation with disease. In other cases, blinded, controlled studies have shown a lack of reproducibility and a lack of correlation with disease. Most of the tests lack biologic plausibility. By understanding the methodology of these tests and the lack of evidence supporting their utility, allergists can prov

"Doctor, I have a Sulfa Allergy": Clarifying the Myths of Cross-Reactivity. Authors: Shah TJ1, Moshirfar M2,3,4, Hoopes PC Sr5. 1 University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA. 2 John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA. cornea2020@me.com. 3 HDR Research Center, Hoopes Vision, Draper, UT, USA. cornea2020@me.com. 4 Utah Lions Eye Bank, Murray, UT, USA. cornea2020@me.com. 5 HDR Research Center, Hoopes Vision, Draper, UT, USA. Abstract: Our purpose is to present an evidence-based approach, directed primarily towards eye-care specialists, clarifying whether certain drugs should or should not be used in patients with sulfonamide allergy. We conducted a literature search using PubMed to identify the risk of ophthalmic-specific drugs in patients with a self-reported sulfonamide allergy. MeSH key words included "sulfonamide" and "hyperse

Fisiopatología del asma Dra. Catalina López (Diciembre de 2018)

Long-term prophylaxis therapy in patients with hereditary angioedema with C1 inhibitor deficiency. Authors: Craig T1, Busse P2, Gower RG3, Johnston DT4, Kashkin JM5, Li HH6, Lumry WR7, Riedl MA8, Soteres D9. 1 Department of Medicine and Pediatrics, Penn State Hershey Allergy, Asthma, and Immunology, Hershey, Pennsylvania. Electronic address: tcraig@pennstatehealth.psu.edu. 2 Icahn School of Medicine at Mount Sinai, New York, New York. 3 Marycliff Clinical Research, Spokane, Washington. 4 Asthma & Allergy Specialists, Charlotte, North Carolina. 5 Jay M Kashkin, MD Allergy, Asthma and Immunology, Fair Lawn, New Jersey. 6 Institute for Asthma and Allergy, Chevy Chase, Maryland. 7 Allergy and Asthma Research Associates, Dallas, Texas. 8 University of California, San Diego, La Jolla, California. 9 Asthma and Allergy Associates PC, Colorado Springs, Colorado. Abstract: OBJECTIVE: To review the criteria for long-term prophylaxis therapy in patients with hereditary angi

Landscape Plant Selection Criteria for the Allergic Patient. Authors: Green BJ1, Levetin E2, Horner WE3, Codina R4, Barnes CS5, Filley WV6. 1 Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa. Electronic address: dox6@cdc.gov. 2 Department of Biological Science, University of Tulsa, Tulsa, Okla. 3 UL Environment, Marietta, Ga. 4 Allergen Science and Consulting, Lenoir, NC. 5 Division of Allergy/Immunology, Children's Mercy Hospital, Kansas City, Mo. 6 Oklahoma Allergy & Asthma Clinic, University of Oklahoma Health Science Center, Oklahoma City, Okla. Abstract: Patients with pollen-related allergies are concerned about the species within their landscape that provoke their symptoms. Allergists are often asked for guidance but few information sources are available to aid patients in the recognition of allergenic plants and str

Cross-Reactive Aeroallergens: Which Need to Cross Our Mind in Food Allergy Diagnosis? Authors:  Faber MA1, Van Gasse AL2, Decuyper II2, Sabato V1, Hagendorens MM2, Mertens C1, Bridts CH1, De Clerck LS1, Ebo DG3. 1 Faculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium. 2 Faculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium; Faculty of Medicine and Health Science, Department of Pediatrics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium. 3 Faculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium. Electronic address: immuno@uantwerpen.be. Abstract: Secondary food allergies due to cross-reactivity between inhalant and food aller

Hypersensitivity reactions to beta-lactams in children Authors:  Francois Graham (a), Sophia Tsabouri (b), and Jean-Christoph Caubet (a) a Division of Pediatric Allergy, Department of Pediatrics, Pediatric Allergy Unit, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland and b Department of Paediatrics, Child Health Department, University of Ioannina, School of Medicine, Ioannina, Greece Abstract: Purpose of review To present the most recent evidence on beta-lactam hypersensitivity reactions in children. Recent findings Drug provocation tests (DPTs) are the gold standard when investigating beta-lactam allergy in children and evidence is increasingly supporting DPTs without skin tests as a safe approach when evaluating children with nonimmediate mild reactions to beta-lactams. Of note, data are limited in the adolescent population, and this attitude may not apply to this age group. Standardization of DPT protocols is required in nonimmediate react

Fisiopatología de la rinitis (Dra. Gloria Gil) Diciembre de 2018

Systemic Treatment for Severe Atopic Dermatitis Authors: Mara Giavina‑Bianchi, Pedro Giavina‑Bianchi Division of Clinical Immunology and Allergy, University of São Paulo School of Medicine, Artur Ramos 178 ap.211A, Jd. América, São Paulo, SP CEP: 01454-904, Brazil Abstract: Atopic dermatitis (AD) is a chronic inflammatory, relapsing disease of the skin, characterized by intense pruritus, maculopapular or vesicular erythematous lesions and scaling, sometimes accompanied by oozing, crusts and/or lichenification that has a negative impact on patients’ quality of life. Prevalence is higher in children, around 15%, and approximately 5% in adults. Before introducing systemic therapy, it is mandatory to review patients’ adherence to the correct use of topical treatments (corticosteroids, calcineurin inhibitors or cresoborole) and/or phototherapy. Ensure that environmental measures are being taken care of, irritant or proven allergic substances are not in use and even if the diagnost

Role of group 2 innate lymphocytes in aspirin-exacerbated respiratory disease pathogenesis Authors: Andrew A. White, M.D.,1 and Taylor A. Doherty, M.D.2 1 Divison of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, California, and 2 Department of Medicine, University of California, San Diego, La Jolla, California Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic nasal polyps, asthma, and airway reactions upon cyclooxygenase (COX) 1 inhibition. AERD is present in up to 7% of adult patients with asthma and the underlying pathogenesis remains largely elusive but prostaglandin D2, cysteinyl leukotrienes, mast cells, and type 2 cytokines are thought to contribute. A wealth of studies have recently implicated group 2 innate lymphoid cells (ILC2), a novel lineage negative lymphocyte population that produces type 2 cytokines, in human allergic disease pathogenesis. Importantly, our recent work identified that ILC2s are recru

Non-IgE-mediated food hypersensitivity Authors:  Lori Connors1, Andrew O’Keefe2, Lana Rosenfeld3,5 and Harold Kim4,5 1 Dalhousie University, Halifax, NS, Canada. 2 Memorial University, St. John’s, NL, Canada. 3 University of Manitoba, Winnipeg, MB, Canada. 4 Western University, London, ON, Canada. 5 McMaster University, Hamilton, ON, Canada. Abstract: Non-immunoglobulin E (IgE)-mediated food hypersensitivity includes a spectrum of disorders that predominantly afect the gastrointestinal tract. This review will focus on the following more common non-IgE-mediated food hypersensitivity syndromes: food protein-induced enterocolitis syndrome (FPIES), allergic proctocolitis (AP), food protein-induced enteropathy (FPE) and celiac disease. FPIES, AP and FPE typically present in infancy and are most commonly triggered by cow’s milk protein or soy. The usual presenting features are profuse emesis and dehydration in FPIES; blood-streaked and mucousy stools in AP; and protracted diarrhe

Generalidades sobre enfermedad respiratoria exacerbada por AINEs Dra. Yurlany Gutiérrez (Diciembre de 2018)

How the Smartphone Is Changing Allergy Diagnostics Authors:  Ana Margarida Pereira1,2 & Cristina Jácome2 & Rute Almeida2 & João Almeida Fonseca1,2,3,4 1 Allergy Unit, Instituto and Hospital CUF, Porto, Portugal 2 CINTESIS- Center for Health Technologies and Information Systems Research, Faculty of Medicine, University of Porto, Porto, Portugal 3 MEDCIDS - Department of Community Medicine, Health Information and Decision, Faculty of Medicine, University of Porto, Porto, Portugal 4 MEDIDA – Medicina, Educação, Investigação, Desenvolvimento e Avaliação, Porto, Portugal Abstract: Purpose of Review Evidence-based clinical diagnosis of allergic disorders is increasingly challenging. Clinical decision support systems implemented in mobile applications (apps) are being developed to assist clinicians in diagnostic decisions at the point of care. We reviewed apps for allergic diseases general diagnosis, diagnostic refinement and diagnostic personalisation. Apps design

Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by In Vitro and In Vivo Tests Authors:  Jorge Sánchez,1,2* Andres Sánchez,1,2,3 Ricardo Cardona1 1 Group of Experimental and Clinical Allergy, IPS Universitaria, University of Antioquia, Medellín, Colombia 2 Foundation for the Development of Medical and Biological Sciences, Cartagena, Colombia 3 Immunology Department, University Corporation Rafael Núñez, Cartagena, Colombia Abstract:  Purpose: Immunoglobulin (Ig) E autoantibodies against thyroid antigens such as thyroid peroxidase (TPO) have been demonstrated in chronic spontaneous urticaria (CSU) patients in higher frequency than healthy subjects. However, if these IgE autoantibodies can trigger urticaria is still a matter of study. The aim of this study was to investigate the relationship between concomitant IgE autoantibodies against thyroid antigens in CSU. Methods: Patients with CSU, healthy subjects and patients with autoimmune thyroid disease (

Managing Severe Asthma: A Role for the Long-Acting Muscarinic Antagonist Tiotropium Authors: Eckard Hamelmann, Children’s Center Bethel, Ev. Klinikum Bielefeld gGmbH, Grenzweg 10, 33617 Bielefeld, Germany Abstract: Severe asthma is associated with substantial morbidity and mortality. Terapies must be maximized to gain control of a patient’s severe asthma; however, avoiding overtreatment is also important. Te mainstays of asthma maintenance treatment are inhaled corticosteroids (ICS) and long-acting �2-agonsits (LABAs), with the option of supplementary add-on treatments. New add-on treatments for severe asthma have emerged over the past two decades, including personalized biological therapies that are guided by a patient’s asthma phenotype. In addition, the long-acting muscarinic antagonist tiotropium has been recommended as an addon treatment for severe asthma. Phase III clinical trials have shown tiotropium in combination with ICS/LABA to be efcacious in patients with se

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children? Authors Licia Pensabene 1,* ,†, Silvia Salvatore 2,†, Enza D’Auria 3,†, Francesca Parisi 1 ,  Daniela Concolino 1 , Osvaldo Borrelli 4 , Nikhil Thapar 4 , Annamaria Staiano 5 ,  Yvan Vandenplas 6 and Miguel Saps 7 1 Department of Medical and Surgical Sciences, Pediatric Unit, University “Magna Graecia” of Catanzaro 88100 Catanzaro, Italy; parisifrancesca01983@gmail.com (F.P.); dconcolino@unicz.it (D.C.) 2 Department of Medicine and Surgery, Section of Pediatrics, University of Insubria,21100 Varese, Italy; silvias.varese@gmail.com 3 Department of Pediatrics, Vittore Buzzi Children’s Hospital-University of Milan, 20154 Milan, Italy; enza.dauria@unimi.it 4 Neurogastroenterology and Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK; Osvaldo.Borrelli@gosh.nhs.uk (O.B.); Nikhil.Thapar@gosh.nhs.uk (N.T.) 5 Depar

Desensibilización a medicamentos  Dr. Liliana Guevara Nov. 2018

Follow-up of patients with negative drug provocation tests to betalactams. Authors:  Chiriac AM1,2, Romano A3,4, Ben Fadhel N1, Gaeta F3, Molinari N5,6,7, Maggioletti M3, Demoly P1,2. 1 Centre hospitalier universitaire de Montpellier, hôpital Arnaud-de-Villeneuve, département de pneumologie et addictologie, univ Montpellier, 34295, Montpellier, France. 2 Sorbonne université, INSERM, institut Pierre-Louis d'épidémiologie et de santé publique, équipe EPAR, 75013, Paris, France. 3 Allergy Unit, Complesso Integrato Columbus, Rome, Italy. 4 IRCCS Oasi Maria S.S, Troina, Italy. 5 Department of Clinical Information, Clinical Research Unit, University Hospital of Montpellier, Montpellier, France. 6 Montpellier University, Montpellier, France. 7 IMAG, UMR 5149, University Hospital of Montpellier, Montpellier, France. Abstract: Drug allergy work-up in betalactam (BL) allergy is probably the most-developed drug-allergy evaluation at present [1]. During the last few years, the

Pruebas de exposición controlada Dra. Ana María Calle (Noviembre de 2018)

Differences in chronic spontaneous urticaria between Europe and Central/ South America: results of the multi-center real world AWARE study Authors: M. Maurer1*, K. Houghton2, C. Costa3, F. Dabove4, L. F. Ensina5,6, A. Giménez-Arnau7, G. Guillet8, G. N. Konstantinou9, M. Labrador-Horrillo10, H. Lapeere11, R. Meshkova12, E. A. Pastorello13, M. Velásquez-Lopera14, L. M. Tamayo Quijano15, C. Vestergaard16 and N. Chapman-Rothe17 1 Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. 2 RTI Health Solutions, Carolina, North, USA. 3 Serviço de Imunoalergologia, Hospital de Santa Maria, Lisbon, Portugal. 4 Center of Medical Specialties Lobos, Buenos Aires, Argentina. 5 CPAlpha Clinical Research Center, São Paulo, Brazil. 6 Hospital Sírio-Libanês, São Paulo, Brazil. 7 Hospital del Mar, Parc de Salut Mar, IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain. 8 Service de Dermato-allergologie, CHU Poitiers, Poit

Liberty Asthma QUEST: Phase 3 Randomized, DoubleBlind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma Authors: W. W. Busse Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin, Madison, WI, USA J. F. Maspero, Fundación CIDEA, Buenos Aires, Argentina K. F. Rabe, Christian Albrechts University, Kiel, Germany A. Papi, University Hospital Santa Anna, Ferrara, Italy S. E. Wenzel, University of Pittsburgh, Pittsburgh, PA, USA L. B. Ford, Asthma and Allergy Center, Bellevue, NE, USA I. D. Pavord Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, UK B. Zhang H. Staudinger G. Pirozzi A. Teper Sanofi, Bridgewater, NJ, USA N. Amin B. Akinlade J. Chao N. M. H. Graham Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA L. Eckert Sanofi, Chilly-Mazarin, France Abstract: Background: Global chroni

Nutritional disorders resulting from food allergy in children Authors:  Rosan Meyer, Department of Paediatrics, Imperial College, London, UK Abstract:  The elimination of food allergens that contribute essential nutrients in paediatrics may lead to the development of nutritional disorders. The most common nutritional disorders include poor growth, micronutrient deficiencies and feeding difficulties. Of the aforementioned, growth faltering has been well studied and is seen as a common presenting factor in paediatric food allergy. However, the use of different criteria and cut-off values makes it difficult to establish the overall effect. The impact of number and type of foods eliminated and comorbidities has yielded varying results, although there seems to be a trend towards worsening growth with atopic dermatitis and the avoidance of cow’s milk. Low micronutrient intake is common in paediatric food allergy; however, a low intake does not necessarily tr

Fisiopatología de asma Presentación Dra. Catalina López (Noviembre de 2018)

A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults Authors:  Lucinda Kennard  1 , Iason Thomas  2 , Krzysztof Rutkowski  2 , Vian Azzu  3 , Patrick F K Yong  4, Bogusia Kasternow  4 , Hannah Hunter  2 , Naeema M O Cabdi  5 , Alla Nakonechna  6 , Annette Wagner  7 1 Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. Electronic address: LK@doctors.org.uk. 2 Department of Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. 3 Department of Medicine (Gastroenterology and Hepatology Subdivision), University of Cambridge, Cambridge, United Kingdom. 4 Department of Allergy and Clinical Immunology, Royal Surrey County Hospital, Guildford, United Kingdom. 5 Department of Allergy, Broadgreen Hospital, Liverpool, United Kingdom. 6 Department of Allergy, Broadgreen Hospital, Liverpool, United Kingdom; L

Comorbidity of Viral Hepatitis and Chronic Spontaneous Urticaria: A Systematic Review Authors:   P Kolkhir  1   2 , N Pereverzina  1 , O Olisova  1 , M Maurer  2 1 Division of Immune-mediated Skin Diseases, Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation. 2 Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany. Abstract:  Chronic viral infections including those by hepatitis B (CHB) virus and hepatitis C (CHC) virus have been reported to be comorbidities of chronic spontaneous urticaria (CSU). Here, we performed the first comprehensive review of the peer-reviewed literature (PubMed, Web of Science and Google Scholar) on the prevalence of CHB and CHC in patients with CSU and vice versa. The prevalence of CHB and CHC in CSU does not appear to be increased. Less than 5% and 2% of patients with CSU have markers of CHB and CHC, respectively, according to most of the

Aspirin-Exacerbated Respiratory Disease Authors:  Andrew A White  1 , Donald D Stevenson  1 1 From the Division of Allergy, Asthma, and Immunology, Scripps Clinic, San Diego, CA DOI:   10.1056/NEJMra1712125

Can we identify patients at risk of life-threatening allergic reactions to food? Authors: P J Turner  1 , J L Baumert  2 , K Beyer  3 , R J Boyle  1 , C-H Chan  4 , A T Clark  5 , R W R Crevel  6 , A DunnGalvin  7 , M Fernández-Rivas  8 , M H Gowland  9 , L Grabenhenrich  10 , S Hardy  4 , G F Houben  11 , J O'B Hourihane  12 , A Muraro  13 , L K Poulsen  14 , K Pyrz  7 , B C Remington  11 , S Schnadt  15 , R van Ree  16 , C Venter  17   18 , M Worm  19 , E N C Mills  20 , G Roberts  18   21 , B K Ballmer-Weber  22 1 Section of Paediatrics (Allergy and Infectious Diseases) & MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK. 2 Food Allergy Research and Resource Program, Department of Food Science and Technology, University of Nebraska, Lincoln, NE, USA. 3 Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany. 4 Food Standards Agency, London, UK. 5 Cambridge University Hospitals NHS

Hypersensitivity Reactions to Antiepileptic Drugs in Children: Epidemiologic, Pathogenetic, Clinical, and Diagnostic Aspects Authors:   Semanur Kuyucu, MD ; Department of Pediatric Allergy and Clinical Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey Jean-Christoph Caubet, MD ; Department of the Child and Adolescent, Pediatric Allergy Unit, Geneva University Hospital, Geneva, Switzerland Abstract: Epilepsy affects approximately 10 million children globally. Antiepileptic drugs (AEDs) are among the most frequent causes of drug hypersensitivity reactions (DHRs), especially severe ones. However, systematic studies about AED hypersensitivity among children are very rare. In this review, we aimed to gather all relevant and important data about different aspects ofDHRs to AEDs in children by conducting a PubMed search including English-language studies published between January 1990 and June 2017. In these studies, aromatic AEDs were mostly incriminated in DHRs, but

Differential Diagnosis of Diaper Dermatitis Authors:  Bernard Cohen, MD ; Johns Hopkins Children’s Center, Baltimore, MD, USA. Abstract:  Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Diaper dermatitis broadly refers to skin disorders that occur in the diaper area, such as skin eruptions triggered by diapers, rashes exacerbated by the diaper, and other events that occur in the diaper area. A number of skin conditions that can occur anywhere on the skin may present with distinctive findings in the diaper area. The fol

Novel vaccines targeting dendritic cells by coupling allergoids to mannan Authors: Cristina Benito-Villalvilla, Irene Soria, José Luis Subiza, Oscar Palomares ; Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain Abstract: Allergen-specific immunotherapy (AIT) is the single disease-modifying treatment for allergy. Clinical trials show AIT to be safe and effective for many patients; however, it still faces problems re- lated to efficacy, safety, long treatment duration and low patient adherence. There has been intensive research to develop alternative strategies, including novel administration routes, adjuvants or hypoal- lergenic molecules. Promising results are reported for someofthem, but clinical progressisstill mod- erate. Allergoids conjugated to nonoxidized man- nan from Saccharomyces cerevisiae have emerged as a novel concept of vaccine targeting dendritic cells (DCs). Preclinical human and anim

Do we still need oral food challenges for the diagnosis of food allergy? Authors: Philippe A. Eigenmann , Department of Child and Adolescent, Pediatric Allergy Unit, University Hospitals of Geneva, Geneva, Switzerland. Abstract:   Food challenges are standard in the diagnosis in patients suspected of being allergic to food. However, their role is regularly questioned due to the time required to perform them, and to their cost and the inherent risk of severe reactions. Food challenges have been challenged by recent advances defining threshold values for food- specific IgE helping to predict the probability of having symptoms to the suspected food. Also, identification of major allergens to various highly allergenic foods such as peanuts or tree nuts has contributed to an increased accuracy of IgE testing. Altogether, these new data have contributed to a better definition of the role of oral food challenges in the diagnosis of food allergy. Oral food challenges are not outda

Mecanismos de inmunoterapia Dr. Jaime Sosa (Noviembre de 2018)

Drug-induced liver injury: a safety review. Authors: García-Cortés M1,2, Ortega-Alonso A1,2, Lucena MI2,3, Andrade RJ1,2; Spanish Group for the Study of Drug-Induced Liver Disease (Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos GEHAM).l. 1 a Instituto de Investigación Biomédica-IBIMA , Hospital Universitario Virgen de la Victoria, Universidad de Málaga , Málaga , Spain. 2 b Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd , Málaga , Spain. 3 c Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria , Universidad de Málaga , Málaga , Spain. Abstract:  Idiosyncratic drug-induced liver injury (DILI) remains one of the most important causes of drug attrition both in the early phases of clinical drug development and in the postmarketing scenario. This is because, in spite of emerging data on genetic susceptibility variants associated to the risk

Current Perspectives on Erythema Multiforme. Authors: Lerch M1, Mainetti C2, Terziroli Beretta-Piccoli B3, Harr T4. 1 Allergy/Dermatology Unit, Department of Internal Medicine, Kantonsspital Winterthur, Winterthur, Switzerland. 2 Department of Dermatology, Bellinzona Regional Hospital, Bellinzona, Switzerland. 3 Epatocentro Ticino, Lugano, Switzerland. 4 Unité d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux Universitaires de Genève HUG, Rue Micheli-du-Crest 24, CH-1211, Genève, Switzerland. Thomas.Harr@hcuge.ch. Abstract:  Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythem

Recent Evidence on the Use  of Tiotropium Bromide  in Pediatric Asthma: Summary  Results of Eight Clinical Trials Ricardo Cardona-Villa, MD, MSc 1,2,* Manuela Tejada-Giraldo, BioEngr, MSc 1 1 Grupo Alergología Clínica y Experimental (GACE), Universidad de Antioquia, Medellín, Colombia *,2 IPS Universitaria - Servicio de Alergología Clínica, Universidad de Antioquia, Carrera 51A No. 62-42, Medellin, Colombia Purpose of Review To collect the existing information on tiotropium as an add-on treat- ment for asthma in children and adolescents. Recent Findings The use of tiotropium bromide in children between 1 and 6 years old. Summary Asthma is a disease that can be difficult to control. For the treatment of this, there is a combination of medications, but often complete control of the disease is not achieved. The addition of tiotropium, a long-acting muscarinic antagonist, to treatment with inhaled corticost

Dupilumab: A New Paradigm for the Treatment of Allergic Diseases Authors: Sastre J1, Dávila I2 1 Allergy Service, Fundación Jiménez Díaz, and Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain 2 Institute for Biomedical Research of Salamanca (IBSAL), Allergy Service, University Hospital of Salamanca, and Department of Biomedical and Diagnostics Sciences, Faculty of Medicine, Salamanca, Spain Abstract: Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the therapeutic options are often very limited. Treatment with systemic corticosteroids and immunosuppressants has adverse effects in the long term, and a significant proportion of patients remain refractory to therapy. In this context, the emerging biological drugs constitute a truly innovative therapeutic approach

Environmental Food Exposure: What Is the Risk of Clinical Reactivity From Cross-Contact and What Is the Risk of Sensitization Authors: William J. Sheehan, MDa,b,c , Steve L. Taylor, PhDd , Wanda Phipatanakul, MD, MSc,e, and Helen A. Brough, PhD, FRCPCHf,g,h aThe Division of Allergy and Immunology, Children’s National Medical Center, Washington, DC b George Washington University School of Medicine and Health Sciences, Washington, DC c The Division of Allergy and Immunology, Boston Children’s Hospital, Boston, Mass d Food Allergy Research and Resource Program, Department of Food Science and Technology, University of Nebraska, Lincoln, Neb e Harvard Medical School, Boston, Mass f Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, Guy’s Hospital, London, United Kingdom g Paediatric Allergy Group, School of Immunology & Microbial Sciences, King’s College London, Guy’s Hospital, London, United Kingd

Página recomendada: Soy experto en alergia La sociedad española de alergología e inmunología clínica tiene dentro de sus objetivos promover la información y educación sanitaria para el público en general, para esto ha creado la pagina web "soy experto en alergia", donde los pacientes pueden encontrar información útil sobre las diferentes patologías alérgicas.  https://soyexpertoenalergia.es

Presentación sobre anafilaxia por el Dr. Stiven Abreu (Noviembre de 2018)

Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches. Autors: de Las Vecillas Sánchez L1,2, Alenazy LA3,4,5, Garcia-Neuer M6, Castells MC7. 1 Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ldelasvecillassanchez@bwh.harvard.edu. 2 Department of Allergy, Marqués de Valdecilla University Hospital-IDIVAL, 39011 Santander, Spain. ldelasvecillassanchez@bwh.harvard.edu. 3 Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy@hms.harvard.edu. 4 Department of Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia. Leila_Alenazy@hms.harvard.edu. 5 Master of Medical Sciences in Immunology Program, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy@hms.harvard.edu. 6 Division of Rheumatology, Immunology and Aller

A cohort study on the risk of lymphoma and skin cancer in users of topical tacrolimus, pimecrolimus, and corticosteroids (Joint European Longitudinal Lymphoma and Skin Cancer Evaluation – JOELLE study) Authors: Castellsague J1, Kuiper JG2, Pottegård A3, Anveden Berglind I4, Dedman D5, Gutierrez L1, Calingaert B6, van Herk-Sukel MP2, Hallas J3, Sundström A4, Gallagher AM5, Kaye JA7, Pardo C8, Rothman KJ7, Perez-Gutthann S1. 1 Department of Epidemiology, RTI Health Solutions, Barcelona, Spain. 2 Department Research, PHARMO Institute for Drug Outcomes Research, Utrecht, the Netherlands. 3 Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark. 4 Centre for Pharmacoepidemiology, Unit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. 5 Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, London, UK. 6 Department Epidemiology, RTI Health Solu

Diagnostic spirometry in primary care: Proposed standards for general practice compliant with American Thoracic Society and European Respiratory Society recommendations: a General Practice Airways Group (GPIAG)1 document, in association with the Association for Respiratory Technology & Physiology (ARTP)2 and Education for Health3 1 www.gpiag.org 2 www.artp.org 3 www.educationforhealth.org.uk. Authors: Levy ML1, Quanjer PH, Booker R, Cooper BG, Holmes S, Small I; General Practice Airways Group. Allergy & Respiratory Research Group, Division of Community Health Sciences:GP section, University of Edinburgh, Scotland, UK. marklevy@animalswild.com Abstract: Primary care spirometry services can be provided by trained primary care staff, peripatetic specialist services, or through referral to hospital-based or laboratory spirometry. The first of these options is the focus of this Standards Document. It aims to provide detailed information for clinicians, managers and hea

Eosinophilic gastrointestinal diseases beyond eosinophilic esophagitis Authors:  Egan M ,  Section of Pediatric Allergy and Immunology, Department of Pediatrics, Children's Hospital of Colorado, Aurora, Colorado; Gastrointestinal Eosinophilic Disease Program, University of Colorado School of Medicine, Aurora, Colorado. Electronic address: maureen.egan@childrenscolorado.org. Furuta GT , Gastrointestinal Eosinophilic Disease Program, University of Colorado School of Medicine, Aurora, Colorado; Digestive Health Institute, Department of Pediatrics, Children's Hospital of Colorado, Aurora, Colorado. Abstract:  OBJECTIVE: Eosinophilic gastrointestinal diseases (EGIDs) are a rare group of disorders that can have varied clinical presentations dependent on the involved segment within the gastrointestinal tract. Eosinophilic gastritis presents with abdominal pain or vomiting, eosinophilic gastroenteritis presents with diarrhea and anemia or hypoalbuminemia, and eosinophi