ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Inhaled Combined Budesonide-Formoterol as Needed in Mild Asthma Authors:  O'Byrne PM1, FitzGerald JM1, Bateman ED1, Barnes PJ1, Zhong N1, Keen C1, Jorup C1, Lamarca R1, Ivanov S1, Reddel HK1. 1 From the Firestone Institute for Respiratory Health, St. Joseph's Healthcare and Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON (P.M.O.), and the Institute for Heart and Lung Health, University of British Columbia, Vancouver (J.M.F.) - both in Canada; the Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa (E.D.B.); Airway Disease Section, National Heart and Lung Institute, Imperial College, London (P.J.B.); State Key Laboratory of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China (N.Z.); AstraZeneca Research and Development, Gothenburg, Sweden (C.K., C.J., S.I.); AstraZeneca Research and Development, Barcelona (R.L.); and Woolcock Institu

IL-24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria Authors:   Schmetzer O1, Lakin E2, Topal FA2, Preusse P2, Freier D2, Church MK2, Maurer M2. 1 Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address: oliver.schmetzer@charite.de. 2 Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Abstract: BACKGROUND: The efficacy of omalizumab (anti-IgE) and increased IgE levels in patients with chronic spontaneous urticaria (CSU) suggest autoallergic mechanisms. OBJECTIVE: We sought to identify autoallergic targets of IgE in patients with CSU. METHODS: Serum samples of patients with CSU together with those of patients with idiopathic anaphylaxis and healthy control subjects (7 of each) were screened for IgE autoantibodies by using an array of more than 9000 proteins. Sera of 1062 patients with CSU and 482 healthy control subjects were use

2019 ARIA Care pathways for allergen immunotherapy. Authors:  Bousquet J1,2, Pfaar O3, Togias A4, Schünemann HJ5, Ansotegui I6, Papadopoulos NG7, Tsiligianni I8, Agache I9, Anto JM10,11,12,13, Bachert C14, Bedbrook A1, Bergmann KC15, Bosnic-Anticevich S16, Bosse I17, Brozek J5, Calderon M18, Canonica GW19, Caraballo L20, Cardona V21, Casale T22, Cecchi L23, Chu DK5, Costa E24, Cruz AA25, Czarlewski W26, Durham SR27, Du Toit G26, Dykewicz M28, Ebisawa M29, Fauquert JL30, Fernandez-Rivas M31, Fokkens WJ32, Fonseca J33, Fontaine JF34, van Wijk RG35, Haahtela T36, Halken S37, Hellings PW38, Ierodiakonou D8, Iinuma T39, Ivancevich JC40, Jacobsen L41, Jutel M42, Kaidashev I43, Khaitov M44, Kalayci O45, Kleine Tebbe J46, Klimek L46, Kowalski ML47, Kuna P48, Kvedariene V49, La Grutta S50, Larenas-Linemann D51, Lau S52, Laune D53, Le L54, Carlsen KL55, Lourenço O56, Malling HJ57, Marien G58, Menditto E59, Mercier G60, Mullol J61, Muraro A62, O'Hehir R63, Okamoto Y39, Pajno GB64, Park

Timing of Food Introduction and the Risk of Food Allergy Authors:   Ferraro V1, Zanconato S2, Carraro S3. 1 Women's and Children's Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy. ferrarovalentina@hotmail.com. 2 Women's and Children's Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy. stefania.zanconato@aopd.veneto.it. 3 Women's and Children's Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy. silvia.carraro@unipd.it. Abstract: Given that the prevalence of pediatric IgE-mediated food allergies (FA) has followed a substantive increase in recent decades, nowadays, a research challenge is to establish whether the weaning strategy can have a role in FA prevention. In recent decades, several studies have demonstrated that delayed exposure to allergenic foods did not reduce the risk of FA, leading to the publication of recent guidelines which recommend against dela

Fisiopatología de la alergia a hongos (Dra. Gloria Gil)

Alergología a cuatro manos: dermatitis atópica por Dra. Gloria Gil y Dr. Ricardo Cardona

Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies. Authors:  Ascott A1, Mulick A2, Yu AM3, Prieto-Merino D2, Schmidt M4, Abuabara K5, Smeeth L2, Roberts A6, Langan SM2. 1 Royal Sussex County Hospital, Eastern Road, Brighton, United Kingdom. Electronic address: annaascott@doctors.org.uk. 2 Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom. 3 Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. 4 Department of Clinical Epidemiology, Aarhus University Hospital, Denmark Department of Cardiology, Regional Hospital West Jutland, Herning, Denmark. 5 Program for Clinical Research, Department of Dermatology, University of California, San Francisco School of Medicine, San Francisco, Calif. 6 Nottingham Support Group for Carers of Children with Eczema, Nottingham, United Kingdom. Abstract:  BACKGROUND: Atopic eczema is a common

Advances in the pathogenesis representing definite outcomes in chronic urticaria. Authors:  Ensina LF1,2, Cusato-Ensina AP3, Cardona R4. 1 Federal University of São Paulo. 2 Hospital Sírio-Libanês. 3 CPAlpha Clinical Research Center, Brazil. 4 Universidad de Antioquia, Colombia. Abstract: PURPOSE OF REVIEW: We reviewed in this article, the recent advances in CSU physiopathology and potential clinical and laboratory biomarkers in CSU. RECENT FINDINGS: In addition to the central role of mast cells in urticaria physiopathology, increased interest in basophils has arisen. Recent data corroborate the autoimmunity pathway as one of the main pathways in mast cell activation. The association of inflammatory cytokines, heat shock proteins and staphylococcal infection with CSU are also reviewed. C-reactive protein, D-dimers, autologous serum skin test, IgE levels and FcεRI expression in basophils have shown their potential as biomarkers for disease duration, activity, severity

Oral corticosteroid use, morbidity, and mortality in asthma: a nationwide prospective cohort study in Sweden. Authors:  Ekström M1, Nwaru BI2,3, Hasvold P4, Wiklund F5, Telg G4, Janson C6. 1 Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund, Sweden. 2 Krefting Research Centre, Institute of Medicine, University of Gothenburg. 3 Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Uppsala University, Uppsala, Sweden. 4 AstraZeneca Nordic-Baltic, Södertälje, Sweden. 5 Statisticon AB, Uppsala, Sweden. 6 Department of Medical Sciences: Respiratory, Allergy and Sleep research, Uppsala University, Uppsala, Sweden. Abstract: BACKGROUND: Patterns and determinants of long-term oral corticosteroid (OCS) use in asthma and related morbidity and mortality are not well-described. In a nationwide asthma cohort in Sweden, we evaluated the patterns and determinants of OCS use and risks

IgE testing can predict food allergy status in patients with moderate to severe atopic dermatitis. Authors:  Frischmeyer-Guerrerio PA1, Rasooly M2, Gu W2, Levin S3, Jhamnani RD3, Milner JD3, Stone K3, Guerrerio AL4, Jones J5, Borres MP6, Brittain E7. 1 Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, Maryland. Electronic address: pamela.guerrerio@nih.gov. 2 Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus, Frederick, Maryland. 3 Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, Maryland. 4 Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland. 5 ImmunoDiagnostics Branch, Thermo Fisher Scientific, Phadia US Inc., Portage, Michigan. 6 Department of Maternal and Child Health, Uppsala University, Uppsala, Sweden. 7 Biostatistics Research Branch, DCR, NIH, Bethesda, Maryland. Abstract: BACKGROUND: Diagnosing food allergy in patients with atopic dermatitis (AD) is complicate

Efficacy and safety of olopatadine/mometasone combination nasal spray for the treatment of seasonal allergic rhinitis. Authors: Gross GN1, Berman G2, Amar NJ3, Caracta CF4, Tantry SK4. 1 Pharmaceutical Research & Consulting Inc, Dallas, TX, US. Electronic address: gary.gross@daac-prc.com. 2 Clinical Research Institute, Inc, Minneapolis, MN, US. 3 Allergy Asthma Research Institute, Waco, TX, US. 4 Glenmark Pharmaceuticals Inc, Paramus, NJ, US. DOI:   10.1016/j.anai.2019.03.017

Wheat allergy in patients with recurrent urticaria. Authors:  Xu YY1,2, Jiang NN1, Wen LP1,2, Li H1,2, Yin J1,2. 1 Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China. 2 Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, China. Abstract:  BACKGROUND: Clinical observation revealed that most of wheat-induced anaphylaxis (WIA)/wheat-dependent exercise-induced anaphylaxis (WDEIA) patients showed a history of recurrent urticaria. We aim to determine the association between recurrent urticaria and anaphylaxis in wheat allergy. METHODS: Population-based cohort study involved patients with WIA (n = 193, including WDEIA n = 104), recurrent urticaria (n = 177), non-wheat-related anaphylaxis (n = 584), atopic disease (excluding anaphylaxis, n = 221) and healthy control (n = 95) from 2009 to 2016. Detailed course of urticaria and anaphylaxis were obtai

Personalized Medicine and Pediatric Asthma. Authors: Pajor NM1, Guilbert TW2. 1 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7041, Cincinnati, OH 45229, USA. 2 Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA; Pulmonary Division, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7041, Cincinnati, OH 45229, USA. Electronic address: Theresa.guilbert@cchmc.org. Abstract: Asthma is a heterogeneous disorder described by a large number of clinical features. A growing body of literature on more specific asthma phenotypes provides evidence for a phenotype-based approach to management in which specific therapies are recommended based on patient and disease characteristics. This understanding, coupled with an increase in the number of available therapies for children with asthma, as well as emerging therapies and phenotypic markers, will allow for improved asthma management in the

Red meat allergy in children and adults Authors: Wilson JM1, Platts-Mills TAE. 1 Division of Allergy and Immunology, University of Virginia, Charlottesville, Virginia, USA. Abstract: PURPOSE OF REVIEW: To highlight recent advances in our understanding of the clinical features, prevalence, and pathophysiology of red meat allergy. RECENT FINDINGS: Allergic reactions to red (i.e. mammalian) meat have historically been considered rare and described primarily in young atopic children. It is now clear that red meat allergy is not uncommon in some parts of the world in other age groups. Strikingly, the majority of these cases relate to specific IgE to galactose-α-1,3-galactose, an oligosaccharide of nonprimate mammals. The mechanism of sensitization in this syndrome relates to bites of certain hard ticks and the clinical reactions often have a delay of 3 to 6 h. An additional form of red meat allergy relates to inhalant sensitization to mammalian proteins. The best characterize

Alergia a pescados y mariscos (Dr. Steven Fuentes)

Fisiopatología de la hipersensibilidad a hongos (Dra. Gloria Gil) Alergia a huevo (Dra. Gloria Gil)

The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma Authors: Kenneth R. Chapman  Frank C. Albers  Bradley Chipps  Xavier Muñoz  Gilles Devouassoux  Miguel Bergna  Dmitry Galkin  Jay Azmi  Dalal Mouneimne  Robert G. Price  Mark C. Liu Abstract: Background Mepolizumab and omalizumab are treatments for distinct but overlapping severe asthma phenotypes. Objective To assess if patients eligible for both biologics but not optimally controlled with omalizumab experience improved asthma control when switched directly to mepolizumab. Methods OSMO was a multicenter, open‐label, single‐arm, 32‐week trial in patients with ≥2 asthma exacerbations in the year prior to enrollment, despite receiving high‐dose inhaled corticosteroids and other controller(s), plus omalizumab (≥4 months). At baseline, patients with blood eosinophil counts ≥150 cells/μL (or ≥300 cells/μL in the prior year) and an Asthma Control Questionnaire (ACQ)‐5 score

Pulmonary Function Testing and Cardiopulmonary Exercise Testing: An Overview. Authors:  Krol K1, Morgan MA1, Khurana S2. 1 Pulmonary and Critical Care Medicine, University of Rochester School of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642, USA. 2 Pulmonary and Critical Care Medicine, Mary Parkes Center for Asthma & Pulmonary Care, University of Rochester School of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642, USA. Electronic address: sandhya_khurana@urmc.rochester.edu. Abstract:  Respiratory symptoms are common reasons for patients to seek care and contribute significantly to use of health care resources. Identifying the underlying etiology of a respiratory symptom is key to management; yet, pinpointing the cause can be a challenge. Familiarity with the tools available to help discern between the various contributing etiologies is crucial in guiding management. A

Non-IgE-mediated cow's milk allergy: Consensus document of the Spanish Society of Paediatric Gastroenterology, Hepatology, and Nutrition (SEGHNP), the Spanish Association of Paediatric Primary Care (AEPAP), the Spanish Society of Extra-hospital Paediatrics and Primary Health Care (SEPEAP), and the Spanish Society of Paediatric ClinicaL Immunology, Allergy, and Asthma (SEICAP). Authors:  Espín Jaime B1, Díaz Martín JJ2, Blesa Baviera LC3, Claver Monzón Á4, Hernández Hernández A5, García Burriel JI6, Mérida MJG7, Pinto Fernández C8, Coronel Rodríguez C9, Román Riechmann E10, Ribes Koninckx C11. 1 Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Unidad de Gestión Clínica de Pediatría, Hospital Universitario Infantil Virgen del Rocío, Sevilla, España. Electronic address: espinj@arrakis.es. 2 Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Oviedo, España. 3 Pedia

Egg OIT in clinical practice (SEICAP II): Maintenance patterns and desensitization state after normalizing the diet. Authors: Martín-Muñoz MF1, Alonso Lebrero E2, Zapatero L2, Fuentes Aparicio V2, Piquer Gibert M3, Plaza Martín AM3, Muñoz C4, Belver MT1, Martorell-Calatayud C5, Martorell-Aragonés A5, Blasco C6, Vilá B6, Gómez C7, Nevot S7, García Martín JM8, Madero R9, Echeverría L10. 1 Allergy Department, Pediatric Hospital La Paz (idiPaz), Madrid, Spain. 2 Allergy Department, Pediatric Hospital Gregorio Marañón, Madrid, Spain. 3 Allergy Section, Pediatric Hospital San Joan de Deu, Barcelona, Spain. 4 Pediatric Allergy Section, Hospital Carlos Haya, Malaga, Spain. 5 Allergy Department, General Hospital of Valencia, Valencia, Spain. 6 Allergy Department, Pediatric Hospital Vall d'Hebron, Barcelona, Spain. 7 Allergy Department, Pediatric Hospital San Joan de Deu, Althaia, Manrresa, Spain. 8 Pediatric Allergy, Cruces Hospital, Bilbao, Spain. 9 Statistical Department,