Recent Evidence on the Use of Tiotropium Bromide in Pediatric Asthma: Summary Results of Eight Clinical Trials

De

Recent Evidence on the Use of Tiotropium Bromide in Pediatric Asthma: Summary Results of Eight Clinical Trials
Ricardo Cardona-Villa, MD, MSc1,2,* Manuela Tejada-Giraldo, BioEngr, MSc1
1Grupo Alergología Clínica y Experimental (GACE), Universidad de Antioquia, Medellín, Colombia
*,2IPS Universitaria - Servicio de Alergología Clínica, Universidad de Antioquia, Carrera 51A No. 62-42, Medellin, Colombia

Purpose of Review To collect the existing information on tiotropium as an add-on treat- ment for asthma in children and adolescents.
Recent Findings The use of tiotropium bromide in children between 1 and 6 years old. Summary Asthma is a disease that can be difficult to control. For the treatment of this, there is a combination of medications, but often complete control of the disease is not achieved. The addition of tiotropium, a long-acting muscarinic antagonist, to treatment with inhaled corticosteroids has been recommended to improve lung function in adults and adolescents who have uncontrolled asthma. Here we present a review of the eight clinical trials that show the use of tiotropium in pediatric patients with asthma. The results demonstrate efficacy in improving lung function (evaluated with different parameters), in both children and adolescents; it also shows the safety of the drug in short and long-term uses.



DOI 10.1007/s40521-018-0194-0

Comentarios

Publicar un comentario

Entradas populares de este blog

La biopsia cutánea en la urticaria crónica: cuándo realizarla, qué buscar y dónde hacerlo

De
La biopsia cutánea en la urticaria crónica: cuándo realizarla, qué buscar y dónde hacerlo Autores: A. López Mateos, M.J. Sánchez Pujol y J.F. Silvestre Salvador Resumen: La urticaria crónica es una entidad relativamente frecuente en la práctica clínica habitual, cuyo diagnóstico se establece de forma clínica. Sin embargo, existen ocasiones en las que está indicada la realización de una biopsia cutánea para confirmar el diagnóstico y diferenciarla de otras patologías que pueden cursar con erupciones urticariformes. En este trabajo revisamos los hallazgos histopatológicos que podemos encontrar tanto en la urticaria crónica como en las patologías que plantean un diagnóstico diferencial. Con base en ello, proponemos un algoritmo que recoge las indicaciones para realizar una biopsia cutánea y la orientación del diagnóstico en función de los hallazgos histopatológicos que encontremos en la misma. DOI:   https://doi.org/10.1016/j.ad.2020.11.016
Leer más

Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management. Fecha: Miércoles 12 de junio

De
Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management. Authors: Castells M1, Butterfield J2. 1 Division of Rheumatology, Allergy, and Immunology, Brigham and Women's Hospital Mastocytosis Center, Boston, Mass. Electronic address: mcastells@bwh.harvard.edu. 2 Mayo Clinic Program for Mast Cell and Eosinophil Disorders, Mayo Clinic, Rochester, Minn. Abstract: Patients with clonal mast cell activation syndromes (MCAS) including cutaneous and systemic mastocytosis (SM) may present with symptoms of mast cell activation, but in addition can have organ damage from the local effects of tissue infiltration by clonal mast cells. Patients with nonclonal MCAS may have chronic or episodic mast cell activation symptoms with an increase in serum tryptase and/or urinary metabolites of histamine, prostaglandin D2, and leukotrienes. Symptoms of MCAS and SM can be managed by blockade of mediator receptors (H1 and H2 antihistamines, leukotriene r...
Leer más

Skin bacterial transplant in atopic dermatitis: Knowns, unknowns and emerging trends. Miércoles 21 de agosto

De
Skin bacterial transplant in atopic dermatitis: Knowns, unknowns and emerging trends. Authors:  Hendricks AJ1, Mills BW2, Shi VY3. 1 University of Arizona College of Medicine, Tucson, AZ USA. 2 Texas Tech Health Sciences Center El Paso Paul L. Foster School of Medicine, El Paso, TX USA. 3 University of Arizona Department of Medicine, Division of Dermatology, Tucson, AZ USA. Electronic address: vshi@email.arizona.edu. Abstract: Dysbiosis is a key pathogenic factor in the cycle of  skin  barrier impairment and inflammation in  atopic   dermatitis  (AD).  Skin  microbial composition in AD is characterized by increased presence of Staphylococcus aureus (S. aureus) and decrease in microbial diversity and commensal  bacterial  species. Attenuation of S. aureus-driven inflammation aids in breaking the itch-scratch cycle via modulation of the cutaneous immune response.  Skin   bacterial   transplant  (SBT), a f...
Leer más