New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?



Authors: Christian A. Devaux , Jean-Marc Rolain , Philippe Colson , Didier Raoult

ABSTRACT
Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.


DOI: 10.1016/j.ijantimicag.2020.105938

Comentarios

  1. I'M TOTALLY FREE FROM HEPATITIS B. FOR OVER 5 YEARS LIVING WITH  IT
     I’m Stephenie Brown, i was diagnosed with Hepatitis B 3 years ago, i lived in pain with the knowledge that i wasn’t going to ever be well again i contacted so many herbal doctors about herbs to cure me and ended up spending some amount of money but i never got better i was determined to get my lifestyle back and to be able to do things am restricted from doing so one day i saw a lady’s post on how Herbalist Dr. James cured her  from Hiv virus with his herbal medicine. I contacted the same Doctor through his email  drjamesherbalmix@gmail.com  we spoke, i told him all that i was going through and he told me not to worry that everything will be more better again so he prepared a herbal medicine and send it to me through DHL courier company and told me the dosage,after 13 days of completing the herbal medicine,i was totally free from Hepatitis,so I went to see a doctor for a blood test ,After taking a sample of my blood for the test the result came out negative,i just can’t deny that i’m the most happiest woman on earth this very moment ,i’m so happy and thanks to Herbalist Doctor JamesHe also told me he cures  diseases   such as ,Cancer,Weak Erection,Wart Remover,Hpv,Herpes,Fibromyalgia,Hiv,Hepatitis b,Liver/Kidney Inflammatory,Epilepsy,Infertility,Fibroid,Diabetes,Dercum,Copd,Back pain
     AND MORE contact him  on
    Email..... Drjamesherbalmix@gmail.com
     What's App...+2348152855846

    ResponderEliminar

Publicar un comentario

Entradas populares de este blog

Contact urticaria: Frequency, elicitors and cofactors in three cohorts (Information Network of Departments of Dermatology; Network of Anaphylaxis; and Department of Dermatology, University Hospital Erlangen, Germany)

ICON: Diagnosis and management of allergic conjunctivitis. Miércoles 25 de marzo

How to Approach Chronic Inducible Urticaria