Antihistamines: Recommended Dosage - Divergence between Clinical Practice and Guideline Recommendations. Fecha: Viernes 01 de febrero
Antihistamines: Recommended Dosage - Divergence between Clinical Practice and Guideline Recommendations. Authors: Manti S, Salpietro C, Cuppari C. Unit of Pediatrics, Department of Pediatrics, “G. Martino” Hospital, University of Messina, Messina, Italy Abstract: The updosing of second-generation antihistamines for chronic urticaria is based on inconsistent findings. Herein, we report data on the treatment of children with chronic spontaneous urticaria (CSU) unresponsive to single doses of second-generation H(1)-antihistamines in whom an increase in antihistamine was performed without improvement and with a high prevalence of adverse events. Thus, it appears that well-controlled, well-designed clinical trials are needed to clarify which nonsedating antihistamines should be used, in what dose, and for how long in patients not responding to the standard treatment, despite the improvement in health care that guidelines help to incorporate. Furthermore, a critical use o...