Next generation anti-S. aureus vaccines: a potential new therapeutic option for atopic dermatitis? Fecha: 11 de octubre de 2018

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Next generation anti-S. aureus vaccines: a potential new therapeutic option for atopic dermatitis?

Authors: 
Clowry J, Pediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland; Clinical Medicine, Trinity College Dublin, Dublin 2, Ireland.
Irvine AD, Pediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland; Clinical Medicine, Trinity College Dublin, Dublin 2, Ireland.
McLoughlin RM, Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin 2, Ireland.

Abstract: 
Disease severity in patients with atopic dermatitis (AD) is directly correlated with colonization by Staphylococcus aureus.1 An increasing body of evidence now also supports a role for S aureus in the pathogenesis of AD in genetically susceptible subjects.2 Increased prevalence of S aureus preceding and coinciding with AD onset in an infant cohort suggests that early skin colonization can contribute to the development of clinical AD.3 However, these findings only partially explain the complex role of this organism given that another birth cohort4 did not demonstrate S aureus colonization before development of infantile AD but did show a protective effect of commensal staphylococci against later development of AD.

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