ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Desensibilización a medicamentos  Dr. Liliana Guevara Nov. 2018

Follow-up of patients with negative drug provocation tests to betalactams. Authors:  Chiriac AM1,2, Romano A3,4, Ben Fadhel N1, Gaeta F3, Molinari N5,6,7, Maggioletti M3, Demoly P1,2. 1 Centre hospitalier universitaire de Montpellier, hôpital Arnaud-de-Villeneuve, département de pneumologie et addictologie, univ Montpellier, 34295, Montpellier, France. 2 Sorbonne université, INSERM, institut Pierre-Louis d'épidémiologie et de santé publique, équipe EPAR, 75013, Paris, France. 3 Allergy Unit, Complesso Integrato Columbus, Rome, Italy. 4 IRCCS Oasi Maria S.S, Troina, Italy. 5 Department of Clinical Information, Clinical Research Unit, University Hospital of Montpellier, Montpellier, France. 6 Montpellier University, Montpellier, France. 7 IMAG, UMR 5149, University Hospital of Montpellier, Montpellier, France. Abstract: Drug allergy work-up in betalactam (BL) allergy is probably the most-developed drug-allergy evaluation at present [1]. During the last few years, the...

Pruebas de exposición controlada Dra. Ana María Calle (Noviembre de 2018)

Differences in chronic spontaneous urticaria between Europe and Central/ South America: results of the multi-center real world AWARE study Authors: M. Maurer1*, K. Houghton2, C. Costa3, F. Dabove4, L. F. Ensina5,6, A. Giménez-Arnau7, G. Guillet8, G. N. Konstantinou9, M. Labrador-Horrillo10, H. Lapeere11, R. Meshkova12, E. A. Pastorello13, M. Velásquez-Lopera14, L. M. Tamayo Quijano15, C. Vestergaard16 and N. Chapman-Rothe17 1 Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. 2 RTI Health Solutions, Carolina, North, USA. 3 Serviço de Imunoalergologia, Hospital de Santa Maria, Lisbon, Portugal. 4 Center of Medical Specialties Lobos, Buenos Aires, Argentina. 5 CPAlpha Clinical Research Center, São Paulo, Brazil. 6 Hospital Sírio-Libanês, São Paulo, Brazil. 7 Hospital del Mar, Parc de Salut Mar, IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain. 8 Service de Dermato-allergologie, CHU Poitiers, Poit...

Liberty Asthma QUEST: Phase 3 Randomized, DoubleBlind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma Authors: W. W. Busse Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin, Madison, WI, USA J. F. Maspero, Fundación CIDEA, Buenos Aires, Argentina K. F. Rabe, Christian Albrechts University, Kiel, Germany A. Papi, University Hospital Santa Anna, Ferrara, Italy S. E. Wenzel, University of Pittsburgh, Pittsburgh, PA, USA L. B. Ford, Asthma and Allergy Center, Bellevue, NE, USA I. D. Pavord Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, UK B. Zhang H. Staudinger G. Pirozzi A. Teper Sanofi, Bridgewater, NJ, USA N. Amin B. Akinlade J. Chao N. M. H. Graham Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA L. Eckert Sanofi, Chilly-Mazarin, France Abstract: Background: Global chroni...

Nutritional disorders resulting from food allergy in children Authors:  Rosan Meyer, Department of Paediatrics, Imperial College, London, UK Abstract:  The elimination of food allergens that contribute essential nutrients in paediatrics may lead to the development of nutritional disorders. The most common nutritional disorders include poor growth, micronutrient deficiencies and feeding difficulties. Of the aforementioned, growth faltering has been well studied and is seen as a common presenting factor in paediatric food allergy. However, the use of different criteria and cut-off values makes it difficult to establish the overall effect. The impact of number and type of foods eliminated and comorbidities has yielded varying results, although there seems to be a trend towards worsening growth with atopic dermatitis and the avoidance of cow’s milk. Low micronutrient intake is common in paediatric food allergy; however, a low intake does not neces...

Fisiopatología de asma Presentación Dra. Catalina López (Noviembre de 2018)

A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults Authors:  Lucinda Kennard  1 , Iason Thomas  2 , Krzysztof Rutkowski  2 , Vian Azzu  3 , Patrick F K Yong  4, Bogusia Kasternow  4 , Hannah Hunter  2 , Naeema M O Cabdi  5 , Alla Nakonechna  6 , Annette Wagner  7 1 Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. Electronic address: LK@doctors.org.uk. 2 Department of Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. 3 Department of Medicine (Gastroenterology and Hepatology Subdivision), University of Cambridge, Cambridge, United Kingdom. 4 Department of Allergy and Clinical Immunology, Royal Surrey County Hospital, Guildford, United Kingdom. 5 Department of Allergy, Broadgreen Hospital, Liverpool, United Kingdom. 6 Department of Allergy, Bro...

Comorbidity of Viral Hepatitis and Chronic Spontaneous Urticaria: A Systematic Review Authors:   P Kolkhir  1   2 , N Pereverzina  1 , O Olisova  1 , M Maurer  2 1 Division of Immune-mediated Skin Diseases, Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation. 2 Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany. Abstract:  Chronic viral infections including those by hepatitis B (CHB) virus and hepatitis C (CHC) virus have been reported to be comorbidities of chronic spontaneous urticaria (CSU). Here, we performed the first comprehensive review of the peer-reviewed literature (PubMed, Web of Science and Google Scholar) on the prevalence of CHB and CHC in patients with CSU and vice versa. The prevalence of CHB and CHC in CSU does not appear to be increased. Less than 5% and 2% of patients with CSU have markers of CHB and CHC, ...

Aspirin-Exacerbated Respiratory Disease Authors:  Andrew A White  1 , Donald D Stevenson  1 1 From the Division of Allergy, Asthma, and Immunology, Scripps Clinic, San Diego, CA DOI:   10.1056/NEJMra1712125

Can we identify patients at risk of life-threatening allergic reactions to food? Authors: P J Turner  1 , J L Baumert  2 , K Beyer  3 , R J Boyle  1 , C-H Chan  4 , A T Clark  5 , R W R Crevel  6 , A DunnGalvin  7 , M Fernández-Rivas  8 , M H Gowland  9 , L Grabenhenrich  10 , S Hardy  4 , G F Houben  11 , J O'B Hourihane  12 , A Muraro  13 , L K Poulsen  14 , K Pyrz  7 , B C Remington  11 , S Schnadt  15 , R van Ree  16 , C Venter  17   18 , M Worm  19 , E N C Mills  20 , G Roberts  18   21 , B K Ballmer-Weber  22 1 Section of Paediatrics (Allergy and Infectious Diseases) & MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK. 2 Food Allergy Research and Resource Program, Department of Food Science and Technology, University of Nebraska, Lincoln, NE, USA. 3 Department of Pediatric Pneumolo...

Hypersensitivity Reactions to Antiepileptic Drugs in Children: Epidemiologic, Pathogenetic, Clinical, and Diagnostic Aspects Authors:   Semanur Kuyucu, MD ; Department of Pediatric Allergy and Clinical Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey Jean-Christoph Caubet, MD ; Department of the Child and Adolescent, Pediatric Allergy Unit, Geneva University Hospital, Geneva, Switzerland Abstract: Epilepsy affects approximately 10 million children globally. Antiepileptic drugs (AEDs) are among the most frequent causes of drug hypersensitivity reactions (DHRs), especially severe ones. However, systematic studies about AED hypersensitivity among children are very rare. In this review, we aimed to gather all relevant and important data about different aspects ofDHRs to AEDs in children by conducting a PubMed search including English-language studies published between January 1990 and June 2017. In these studies, aromatic AEDs were mostly incriminated in DHRs,...

Differential Diagnosis of Diaper Dermatitis Authors:  Bernard Cohen, MD ; Johns Hopkins Children’s Center, Baltimore, MD, USA. Abstract:  Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Diaper dermatitis broadly refers to skin disorders that occur in the diaper area, such as skin eruptions triggered by diapers, rashes exacerbated by the diaper, and other events that occur in the diaper area. A number of skin conditions that can occur anywhere on the skin may present with distinctive findings in the diaper area...

Novel vaccines targeting dendritic cells by coupling allergoids to mannan Authors: Cristina Benito-Villalvilla, Irene Soria, José Luis Subiza, Oscar Palomares ; Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain Abstract: Allergen-specific immunotherapy (AIT) is the single disease-modifying treatment for allergy. Clinical trials show AIT to be safe and effective for many patients; however, it still faces problems re- lated to efficacy, safety, long treatment duration and low patient adherence. There has been intensive research to develop alternative strategies, including novel administration routes, adjuvants or hypoal- lergenic molecules. Promising results are reported for someofthem, but clinical progressisstill mod- erate. Allergoids conjugated to nonoxidized man- nan from Saccharomyces cerevisiae have emerged as a novel concept of vaccine targeting dendritic cells (DCs). Preclinical human and ...

Do we still need oral food challenges for the diagnosis of food allergy? Authors: Philippe A. Eigenmann , Department of Child and Adolescent, Pediatric Allergy Unit, University Hospitals of Geneva, Geneva, Switzerland. Abstract:   Food challenges are standard in the diagnosis in patients suspected of being allergic to food. However, their role is regularly questioned due to the time required to perform them, and to their cost and the inherent risk of severe reactions. Food challenges have been challenged by recent advances defining threshold values for food- specific IgE helping to predict the probability of having symptoms to the suspected food. Also, identification of major allergens to various highly allergenic foods such as peanuts or tree nuts has contributed to an increased accuracy of IgE testing. Altogether, these new data have contributed to a better definition of the role of oral food challenges in the diagnosis of food allergy. Oral food challenges are not o...

Mecanismos de inmunoterapia Dr. Jaime Sosa (Noviembre de 2018)

Drug-induced liver injury: a safety review. Authors: García-Cortés M1,2, Ortega-Alonso A1,2, Lucena MI2,3, Andrade RJ1,2; Spanish Group for the Study of Drug-Induced Liver Disease (Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos GEHAM).l. 1 a Instituto de Investigación Biomédica-IBIMA , Hospital Universitario Virgen de la Victoria, Universidad de Málaga , Málaga , Spain. 2 b Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd , Málaga , Spain. 3 c Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria , Universidad de Málaga , Málaga , Spain. Abstract:  Idiosyncratic drug-induced liver injury (DILI) remains one of the most important causes of drug attrition both in the early phases of clinical drug development and in the postmarketing scenario. This is because, in spite of emerging data on genetic susceptibility variants associated to the r...

Current Perspectives on Erythema Multiforme. Authors: Lerch M1, Mainetti C2, Terziroli Beretta-Piccoli B3, Harr T4. 1 Allergy/Dermatology Unit, Department of Internal Medicine, Kantonsspital Winterthur, Winterthur, Switzerland. 2 Department of Dermatology, Bellinzona Regional Hospital, Bellinzona, Switzerland. 3 Epatocentro Ticino, Lugano, Switzerland. 4 Unité d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux Universitaires de Genève HUG, Rue Micheli-du-Crest 24, CH-1211, Genève, Switzerland. Thomas.Harr@hcuge.ch. Abstract:  Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythem...

Recent Evidence on the Use  of Tiotropium Bromide  in Pediatric Asthma: Summary  Results of Eight Clinical Trials Ricardo Cardona-Villa, MD, MSc 1,2,* Manuela Tejada-Giraldo, BioEngr, MSc 1 1 Grupo Alergología Clínica y Experimental (GACE), Universidad de Antioquia, Medellín, Colombia *,2 IPS Universitaria - Servicio de Alergología Clínica, Universidad de Antioquia, Carrera 51A No. 62-42, Medellin, Colombia Purpose of Review To collect the existing information on tiotropium as an add-on treat- ment for asthma in children and adolescents. Recent Findings The use of tiotropium bromide in children between 1 and 6 years old. Summary Asthma is a disease that can be difficult to control. For the treatment of this, there is a combination of medications, but often complete control of the disease is not achieved. The addition of tiotropium, a long-acting muscarinic antagonist, to treatment with inh...

Dupilumab: A New Paradigm for the Treatment of Allergic Diseases Authors: Sastre J1, Dávila I2 1 Allergy Service, Fundación Jiménez Díaz, and Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain 2 Institute for Biomedical Research of Salamanca (IBSAL), Allergy Service, University Hospital of Salamanca, and Department of Biomedical and Diagnostics Sciences, Faculty of Medicine, Salamanca, Spain Abstract: Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the therapeutic options are often very limited. Treatment with systemic corticosteroids and immunosuppressants has adverse effects in the long term, and a significant proportion of patients remain refractory to therapy. In this context, the emerging biological drugs constitute a truly innovative therapeutic approach...

Environmental Food Exposure: What Is the Risk of Clinical Reactivity From Cross-Contact and What Is the Risk of Sensitization Authors: William J. Sheehan, MDa,b,c , Steve L. Taylor, PhDd , Wanda Phipatanakul, MD, MSc,e, and Helen A. Brough, PhD, FRCPCHf,g,h aThe Division of Allergy and Immunology, Children’s National Medical Center, Washington, DC b George Washington University School of Medicine and Health Sciences, Washington, DC c The Division of Allergy and Immunology, Boston Children’s Hospital, Boston, Mass d Food Allergy Research and Resource Program, Department of Food Science and Technology, University of Nebraska, Lincoln, Neb e Harvard Medical School, Boston, Mass f Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, Guy’s Hospital, London, United Kingdom g Paediatric Allergy Group, School of Immunology & Microbial Sciences, King’s College London, Guy’s Hospital, London, United Kingd...

Página recomendada: Soy experto en alergia La sociedad española de alergología e inmunología clínica tiene dentro de sus objetivos promover la información y educación sanitaria para el público en general, para esto ha creado la pagina web "soy experto en alergia", donde los pacientes pueden encontrar información útil sobre las diferentes patologías alérgicas.  https://soyexpertoenalergia.es

Presentación sobre anafilaxia por el Dr. Stiven Abreu (Noviembre de 2018)

Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches. Autors: de Las Vecillas Sánchez L1,2, Alenazy LA3,4,5, Garcia-Neuer M6, Castells MC7. 1 Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ldelasvecillassanchez@bwh.harvard.edu. 2 Department of Allergy, Marqués de Valdecilla University Hospital-IDIVAL, 39011 Santander, Spain. ldelasvecillassanchez@bwh.harvard.edu. 3 Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy@hms.harvard.edu. 4 Department of Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia. Leila_Alenazy@hms.harvard.edu. 5 Master of Medical Sciences in Immunology Program, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy@hms.harvard.edu. 6 Division of Rheumatology, Immunology and Aller...