ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Evaluation and Management of Penicillin Allergy: A Review. Authors: Shenoy ES1,2,3, Macy E4, Rowe T5, Blumenthal KG1,6,7. 1 Harvard Medical School, Boston, Massachusetts. 2 Infection Control Unit, Massachusetts General Hospital, Boston. 3 Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston. 4 Department of Allergy, Southern California Permanente Medical Group, San Diego Medical Center. 5 General Internal Medicine and Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 6 Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston. 7 Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital, Boston. Abstract IMPORTANCE: β-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics t...

Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America. A uthors: Torres MJ1,2, Romano A3,4, Celik G5, Demoly P6, Khan DA7, Macy E8, Park M9, Blumenthal K10, Aberer W11, Castells M12, Barbaud A13, Mayorga C#14, Bonadonna P#15. 1 Allergy Unit, National Network ARADyAL, IBIMA-Regional University Hospital of Malaga-UMA (Pavilion C), Plaza del Hospital Civil, 29009 Malaga, Spain. 2 BIONAND-Andalusian Centre for Nanomedicine and Biotechnology, Malaga, Spain. 3 Allergy Unit, Presidio Columbus, Rome, Italy. 4 IRCCS Oasi Maria S.S., Troina, Italy. 5 Department of Chest Diseases, Division of Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey. 6 Hôpital Arnaud de Villeneuve, University Hospital of Montpellier and Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, 75013 Paris, France. 7 Department of Internal Medicine, Division of Allergy and Immunology, Unive...

Aquagenic cutaneous disorders Authors: Wang F1, Zhao YK2, Luo ZY1, Gao Q1, Wu W3, Sarkar R4, Luo DQ2. 1 Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 2 Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 3 Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. 4 Department of Dermatology, Maulana Azad Medical college and LNJP Hospital, New Delhi, India. Abstract Aquagenic cutaneous disorders, which include aquagenic urticaria, aquagenic pruritus, and aquagenic acrokeratoderma, are a group of rare diseases characterized by skin lesions or discomfort induced by brief contact with water. Aquagenic urticaria is characterized by pruritic wheals that occur at the sites of water contact, either immediately or within minutes, and disappear within 30-60 min after water removal. Aquagenic pruritus presents ...

Capítulo A2.  Allergens and the Allergenic Composition of Source Materials Authors: Ronald van Ree, Rob C. Aalberse Abstract:  Many different types of proteins are allergenic. The context of a protein may be a major determinant for its allergenicity. Some IgE inducers are not really allergens at all because they don’t induce symptoms. This negatively impacts specificity of diagnostic tests, certainly of extract-based tests but also still of molecular tests. Allergen extracts are imperfect but not yet obsolete. Molecular sensitization profiles: potential biomarkers for disease phenotypes and progression The initial response to an allergen source is possibly characterized by IgE antibodies to one or two “initiator” allergens. EAACI link:  https://www.eaaci.org/documents/Molecular_Allergology-web.pdf

The diagnostic value of APT for food allergy in children: a systematic review and meta-analysis. Authors: Luo Y1, Zhang GQ1, Li ZY1. 1 Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Department of Gastroenterology, Children's Hospital of Chongqing Medical University, Chongqing, China. Abstract BACKGROUND: The role of atopy patch test (APT) in the diagnosis of food allergy (FA) remains largely controversial. In our meta-analysis, we aimed to evaluate the accuracy of APT for diagnosing FA in children. METHODS: Pubmed, Embase and Cochrane Library were searched for studies regarding the diagnostic value of APT for FA in children compared to oral food challenge (double-blind placebo-controlled food challenge and/or open food challenge). The last search was conducted on November 11, 2017. Two revie...

Controversies in Allergy: Is Skin Testing Required Prior to Drug Challenges? Authors:  Macy E1, Ensina LF2. 1 Department of Allergy, Southern California Permanente Medical Group, San Diego Medical Center, San Diego, Calif. Electronic address: eric.m.macy@kp.org. 2 Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil; Hospital Sírio-Libanês, São Paulo, Brazil. DOI: http://doi.org/10.1016/j.jaip.2018.09.008

Omalizumab for the Treatment of Solar Urticaria: Case Series and Systematic Review of the Literature. Authors : Snast I1, Kremer N1, Lapidoth M1, Enk CD2, Tal Y3, Rosman Y4, Confino-Cohen R4, Hodak E1, Levi A5. 1 Photodermatosis Clinic, Department of Dermatology, Rabin Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 2 Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. 3 Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. 4 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar-Saba, Israel. 5 Photodermatosis Clinic, Department of Dermatology, Rabin Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: docalevi@gmail.com. Abstract: BACKGROUND: Solar urtic...

Capítulo A1: Alergollogy from extracts to molecules: Integrating tadition with innovation. Authors : Paolo Maria Matricardi, Jörg Kleine-Tebbe, Hans Jürgen Hoffmann, Rudolf Valenta, Markus Ollert.  Abstract:  The transition from allergen extracts to molecules for the diagnostic work-up of IgE mediated reactions/diseases has great potential, but requires detailed knowledge and intelligent interpretation Diagnostic algorithms traditionally start with the history (“top-down”), followed by skin tests, then IgE assays adding allergen molecules for “component-resolved diagnosis” (CRD) Novel diagnostics invert the test order (“bottom-up”) and start with a multiplex (i.e. microarray-based) IgE assay and many components. Then the history is reviewed for concordance to establish a broad CRD Combining both strategies, “top-down” and “bottom-up”, creates a “U-shaped” sequence. Traditional diagnostic work-up can thus be expanded by a broad screening for IgE-binding molecule...

A modified oral food challenge in children with food protein-induced enterocolitis syndrome. Authors: Barni S1, Sarti L1, Mori F1, Liotti L2, Pucci N1, Novembre E1. 1 Allergy Unit, A. Meyer Children's Hospital, Florence, Italy. 2 Pediatric Unit, Hospital of Senigallia, Senigallia, Italy. DOI:  10.1111/cea.13477

Authors:  Konstantinou GN#1, Konstantinou GN#2. Author information 1 Department of Psychiatry, 251 Hellenic Airforce V. A. General Hospital, Athens, Greece. 2 Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Eleftheriou Benizelou Street, Kalamaria, 55 133 Thessaloniki, Greece. Contributed equally Abstract: BACKGROUND: Dermatological illness can affect the quality of life and may coexist with psychiatric disorders. OBJECTIVE: The aim of this review was to systematically evaluate the published evidence of any psychiatric disorders that may coexist with chronic urticaria (CU) and any effect psychiatric interventions may have on CU. METHODS: Following the Cochrane guidance, we conducted a systematic literature search using web-based search engines provided by PubMed (for Medline database), Google Scholar and Scopus for studies that have investigated the existence of psychiatric comorbidity in patients with CU. To be inc...

A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults. Authors:  Kennard L1, Thomas I2, Rutkowski K2, Azzu V3, Yong PFK4, Kasternow B4, Hunter H2, Cabdi NMO5, Nakonechna A6, Wagner A7. 1 Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. Electronic address: LK@doctors.org.uk. 2 Department of Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. 3 Department of Medicine (Gastroenterology and Hepatology Subdivision), University of Cambridge, Cambridge, United Kingdom. 4 Department of Allergy and Clinical Immunology, Royal Surrey County Hospital, Guildford, United Kingdom. 5 Department of Allergy, Broadgreen Hospital, Liverpool, United Kingdom. 6 Department of Allergy, Broadgreen Hospital, Liverpool, United Kingdom; Liverpool Hope University, Liverpool, United Kingdom. 7 Department of Aller...

The first year of treatment predicts the prognosis of asthma over 25 y-A prospective study. Authors:  Kauppinen R1, Vilkka V1, Sintonen H2, Hedman J1 . 1 Pulmonary Department, South Karelia Central Hospital, Lappeenranta, Finland. 2 Department of Public Health, University of Helsinki, Helsinki, Finland. Abstract: BACKGROUND: An investigator-driven, real-life follow-up study of adult-onset steroid-naïve, newly diagnosed asthma (162 patients) to investigate the treatment results over the 25-year course of the disease and whether the first treatment year's forced expiratory volume in one second (FEV1 ) predicts the long-term prognosis. METHODS: Eighty-three per cent of the 133 living patients participated in the 25-year examinations. At this visit, basic asthma examinations including lung function, as well as questionnaires for health-related quality of life (HRQoL), GINA and the Asthma Control Test, were used for evaluation. The use of medication and remission ...

Pruritus in allergy and immunology. Authors:  Yang TB1, Kim BS2. 1 Center for the Study of Itch, Washington University School of Medicine, St Louis, Mo; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, Mo. 2 Center for the Study of Itch, Washington University School of Medicine, St Louis, Mo; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, Mo; Department of Anesthesiology, Washington University School of Medicine, St Louis, Mo; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Mo. Electronic address: briankim@wustl.edu. Abstract:  Although evolutionarily conserved to expel ectoparasites and aid in the clearance of toxins and noxious environmental stimuli from the host, the type 2 immune response can become pathologic in the setting of a variety of allergic disorders. Itch can be a behavioral extension of type 2 immuni...

Does understanding endotypes translate to better asthma management options for all? Authors:  Custovic A1, Henderson J2, Simpson A3. 1 Department of Paediatrics, Imperial College London, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: a.custovic@imperial.ac.uk. 2 MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. 3 Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Abstract:  Despite the development of novel treatments, improvement in the design of delivery devices, and new technologies for monitoring and improving adherence, the burden of asthma is not decreasing. Predicting an individual patient's response to asthma drugs ...

Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Authors:  Irahara M1,2,3, Shinahara W1, Mayumi S3, Ogawa Y4, Shitsukawa K5, Kenji K1, Ohya Y2, Saito H6, Kagami S3, Hiroshi K1. 1 Division of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Tokushima, Japan. 2 Allergy Center, National Center for Child Health and Development, Tokyo, Japan. 3 Department of Pediatrics, Graduate School of Medicine, Tokushima University, Tokushima, Japan. 4 Department of Pediatrics, Tokushima Prefecture Naruto Hospital, Tokushima, Japan. 5 Department of Obstetrics and Gynecology, Tokushima Prefecture Naruto Hospital, Tokushima, Japan. 6 Department of Allergy and Immunology, Research Institute, National Center for Child Health and Development, Tokyo, Japan. Abstract: Hen's egg is one of the most common causes of food allergy during infancy in many countries (1). Ovomucoid (OVM) is a major component of egg white (EW) pr...