ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Alérgenos del maní y frutos secos (Dr. Jaime Sosa Moreno)

Inmunomoduladores en infecciones respiratorias recurrentes (Dra. Ana María Calle)

Comparing azathioprine with cyclosporine in the treatment of antihistamine refractory chronic spontaneous urticaria: A randomized prospective active-controlled non-inferiority study. Authors: Pathania YS1, Bishnoi A1, Parsad D1, Kumar A2, Kumaran MS1 1 Department of Dermatology, Venereology and Leprology, PGIMER, Sector 12, Chandigarh, 160012, India. 2 National Institute of Nursing Education, PGIMER, Sector 12, Chandigarh, 160012, India. Abstract: BACKGROUND: Literature on the efficacy of azathioprine in antihistamine refractory chronic spontaneous urticaria (CSU) is limited. OBJECTIVE: To compare the efficacy and safety of azathioprine with respect to cyclosporine in the treatment of refractory CSU. METHODS: In this prospective, randomized, active-controlled, non-inferiority study, 80 patients of refractory CSU were administered either cyclosporine (group A, n ​= ​40) or azathioprine (group B, n ​= ​40) for 90 days and followed up for further 90 days. The treatment ...

Validity and responsiveness of the Urticaria Activity and Impact Measure: A new patient-reported tool. Authors:   Maurer M1, Mathias SD2, Crosby RD3, Rajput Y4, Zazzali JL5. 1 Dermatological Allergology, Department of Dermatology and Allergy, Charite-Universitätsmedizin Berlin, Berlin, Germany. 2 Health Outcomes Solutions, Winter Park, Florida. 3 Health Outcomes Solutions, Winter Park, Florida; Neuropsychiatric Research Institute, Fargo, North Dakota; University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota. 4 Genentech Inc, South San Francisco, California. Electronic address: rajput.yamina@gene.com. 5 Genentech Inc, South San Francisco, California. Abstract: BACKGROUND: Chronic spontaneous urticaria (CSU), also known as chronic idiopathic urticaria, may produce hives, itch, and angioedema. The Urticaria Activity and Impact Measure (U-AIM) is a newly developed 9-item patient-reported measure designed for use in routine clinical practice...

Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis Authors:   Lien Calus1, Nicholas Van Bruaene1, Cedric Bosteels1, Sarah Dejonckheere1, Thibaut Van Zele1, Gabrielle Holtappels1, Claus Bachert1,2 and Philippe Gevaert1* 1 Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium Abstract: Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical treatment. We monitored recurrence and revision surgery over 12 years after endoscopic sinus surgery in CRSwNP patients. Methods: In this prospective cohort study, 47 patients with CRSwNP, who underwent primary or revision extended endoscopic sinus surgery, were followed. Clinical symptoms and total nasal endoscopic polyp scor...

Reduced need for surgery in severe nasal polyposis with mepolizumab: Randomized trial. Authors: Bachert C1, Sousa AR2, Lund VJ3, Scadding GK3, Gevaert P4, Nasser S5, Durham SR6, Cornet ME7, Kariyawasam HH3, Gilbert J8, Austin D2, Maxwell AC9, Marshall RP2, Fokkens WJ7. 1 Upper Airways Research Laboratory and Department of Oto-Rhino-Laryngology, Ghent University and Ghent University Hospital, Ghent, Belgium; Division of ENT Diseases, CLINTEC, Karolinska Institute, University of Stockholm, Stockholm, Sweden. Electronic address: Claus.Bachert@UGent.be. 2 Respiratory Therapy Unit, GlaxoSmithKline, Stockley Park, Uxbridge, United Kingdom. 3 Royal National Throat, Nose and Ear Hospital, UCLH London, London, United Kingdom. 4 Upper Airways Research Laboratory and Department of Oto-Rhino-Laryngology, Ghent University and Ghent University Hospital, Ghent, Belgium. 5 Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. 6 Allergy and ...

Omalizumab for Chronic Urticaria in Children Less than 12 Years of Age: A Systematic Review. Authors:  Al-Shaikhly T1, Rosenthal JA1, Ayars AG1, Petroni DH2. 1 Department of Medicine, University of Washington, Seattle, Washington, USA. 2 Department of Medicine, University of Washington, Seattle, Washington, USA; Northwest Asthma and Allergy Center, Seattle, Washington, USA; Seattle Allergy & Asthma Research Institute, Seattle, Washington, USA. Electronic address: dpetroni@seattleallergy.org. DOI:   10.1016/j.anai.2019.05.003

EAACI Guidelines on Allergen Immunotherapy: House dust mite-driven allergic asthma. Authors: Agache I1, Lau S2, Akdis CA3,4, Smolinska S5,6, Bonini M7, Cavkaytar O8, Flood B9, Gajdanowicz P5, Izuhara K10, Kalayci O11, Mosges R12, Palomares O13, Papadopoulos NG14,15, Sokolowska M3,4, Angier E16, Fernandez-Rivas M17, Pajno G18, Pfaar O19, Roberts GC20,21,16, Ryan D22,23, Sturm GJ24,25, van Ree R26,27, Varga EM28, van Wijk RG29, Yepes-Nuñez JJ30, Jutel M5,6. 1 Faculty of Medicine, Department of Allergy and Clinical Immunology, Transylvania University Brasov, Brasov, Romania. 2 Department for Pediatric Pneumology, Immunology and Intensive Care, Charité Universität Medizin, Berlin, Germany. 3 University of Zürich, Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland. 4 Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland. 5 Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland. 6 "ALL-MED...

Alergia a la proteína de la leche de vaca (Dra. Catalina López)

Randomized trial of peanut consumption in infants at risk for peanut allergy. Authors: Du Toit G1, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G; LEAP Study Team. 1 From the Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London and Guy's and St. Thomas' National Health Service Foundation Trust, London (G.D.T., S.R., A.F.S., H.A.B., M.B., M.F., V.T., G.L.), and the University of Southampton and National Institute for Health Research Respiratory Biomedical Research Unit, Southampton and David Hide Centre, Newport, Isle of Wight (G.R.) - both in the United Kingdom; the Division of Hematology-Oncology, Department of Medicine (P.H.S.), and the Immune Tolerance Network (D.P.), University of California, San Francisco, San Francisco; Rho Federal Systems Division, Chapel Hill, NC (H.T.B., M.L.S.); and the National Institu...

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial Authors: Schmidt RM1, Pilmann Laursen R2, Bruun S1,3, Larnkjaer A2, Mølgaard C2, Michaelsen KF2, Høst A1,3. 1 Hans Christian Andersen Hospital for Children and Adolescents, Odense University Hospital, Odense C, Denmark. 2 Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark. 3 Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense C, Denmark. Abstract: BACKGROUND: Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization. METHODS: In this double-blind, placebo-controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillu...

Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management. Authors: Castells M1, Butterfield J2. 1 Division of Rheumatology, Allergy, and Immunology, Brigham and Women's Hospital Mastocytosis Center, Boston, Mass. Electronic address: mcastells@bwh.harvard.edu. 2 Mayo Clinic Program for Mast Cell and Eosinophil Disorders, Mayo Clinic, Rochester, Minn. Abstract: Patients with clonal mast cell activation syndromes (MCAS) including cutaneous and systemic mastocytosis (SM) may present with symptoms of mast cell activation, but in addition can have organ damage from the local effects of tissue infiltration by clonal mast cells. Patients with nonclonal MCAS may have chronic or episodic mast cell activation symptoms with an increase in serum tryptase and/or urinary metabolites of histamine, prostaglandin D2, and leukotrienes. Symptoms of MCAS and SM can be managed by blockade of mediator receptors (H1 and H2 antihistamines, leukotriene r...

An evaluation of fevipiprant for the treatment of asthma: a promising new therapy? Authors: Murillo JC1, Dimov V2, Gonzalez-Estrada A3. 1 a Division of Allergy, Asthma, and Clinical Immunology , Mayo Clinic , Scottsdale , Arizona , USA. 2 b Department of Allergy and Clinical Immunology , Cleveland Clinic , Weston , Florida , USA. 3 c Division of Pulmonary, Allergy, and Sleep Medicine , Mayo Clinic , Jacksonville , Florida , USA. Abstract: Asthma is a heterogeneous disease characterized by chronic airway inflammation that affects more than 230 million people worldwide. Current guidelines recommend an escalating stepwise decision model for the management of asthma. However, disease control continues to be a challenge, particularly in patients with severe asthma. Biologics have proven to be an effective add-on treatment especially in eosinophilic or type 2 airway disease. Comparatively, pre-biologics may represent a successful novel therapy. Fevipiprant (QAW039) is a selectiv...

Detection of serum and salivary IgE and IgG1 immunoglobulins specific for diagnosis of food allergy. Authors:  Nunes MPO1, van Tilburg MF1, Tramontina Florean EOP1, Guedes MIF1. 1 Laboratory of Biotechnology and Molecular Biology, State University of Ceará, Fortaleza, Ceará, Brazil. Abstract: Given the growing incidence and prevalence of life-threatening food allergies, health concerns have raised new perspectives for in vivo and in vitro diagnostic methodologies, pointing to saliva as a promising material, already used to diagnose other pathologies. Based on the above considerations, this study aimed to verify the possible use of saliva for the detection of IgE and IgG1 in the diagnosis of food allergy. This was a randomized, cross-sectional clinical study with a quantitative approach, developed at a hospital referral center in allergy in the state of Ceará, from January to July 2015. The sample consisted of 36 children of both sexes, aged between 1 and 60 months, with ...

Pregnancy Outcomes in the Omalizumab Pregnancy Registry and a Disease-matched Comparator Cohort. Authors:  Namazy JA1, Blais L2, Andrews EB3, Scheuerle AE4, Cabana MD5, Thorp JM6, Umetsu DT7, Veith JH7, Sun D7, Kaufman DG7, Covington DL8, Mukhopadhyay S9, Fogel RB10, Lopez-Leon S10, Spain CV11. 1 Scripps Clinic, San Diego, CA. 2 Université de Montréal, Montréal, QC, Canada. 3 RTI Health Solutions, Research Triangle Park, NC. 4 University of Texas Southwestern Medical Center, Dallas, TX. 5 University of California, San Francisco, San Francisco, CA. 6 University of North Carolina School of Medicine, Chapel Hill, NC. 7 Genentech, Inc., South San Francisco, CA. 8 Evidera, Wilmington, NC. 9 Novartis Pharma AG, Basel, Switzerland. 10 Novartis Pharmaceuticals Corp., East Hanover, NJ. 11 Genentech, Inc., South San Francisco, CA. Electronic address: spainc@gene.com Abstract: BACKGROUND: The EXPECT pregnancy registry was a prospective observational study established in ...

IgE Mediated Autoallergy against Thyroid Peroxidase – A Novel Pathomechanism of Chronic Spontaneous Urticaria? Authors: Altrichter S1, Peter HJ, Pisarevskaja D, Metz M, Martus P, Maurer M. 1 Department of Dermatology and Allergy, Allergie-Centrum-Charité/ECARF, Charité-Universitätsmedizin Berlin, Berlin, Germany Abstract: BACKGROUND: Chronic spontaneous urticaria (csU), which is characterized by recurrent episodes of mast cell-driven wheal and flare-type skin reactions, is often associated with elevated total IgE levels and thyroid autoimmunity. We speculate that some csU patients express IgE autoantibodies against thyroid antigens such as thyroid peroxidase (TPO), which could bind to skin mast cells and induce their activation. METHODS: We developed and used a site-directed human IgE capture ELISA to quantify IgE-anti-TPO. We used this assay and investigated csU patients (n = 478) and healthy control subjects (n = 127) for IgE-anti-TPO and then assessed IgE-anti-TP...

New Directions in Pediatric Asthma Authors:  Bacharier LB1, Guilbert TW2. 1 Department of Pediatrics, Washington University School of Medicine in St. Louis, Campus Box 8116, 660 South Euclid Avenue, St Louis, MO 63110, USA. 2 Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA; Pulmonary Division, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7041, Cincinnati, OH 45229, USA. Electronic address: Theresa.Guilbert@cchmc.org. Abstract: Childhood asthma affects many children placing them at significant risk for health care utilization and school absences. Several new developments relevant to the field of pediatric asthma have occurred over the last 5 years; yet, there is much more to learn. It is poorly understood how to prevent the disease, optimally address environmental challenges, or effectively manage poor adherence. Moreover, it is not clear how to customize therapy by asthma phenotype, age group, high risk groups, or seve...