ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Antihistamines: Recommended Dosage - Divergence between Clinical Practice and Guideline Recommendations. Authors: Manti S, Salpietro C, Cuppari C. Unit of Pediatrics, Department of Pediatrics, “G. Martino” Hospital, University of Messina, Messina, Italy Abstract:  The updosing of second-generation antihistamines for chronic urticaria is based on inconsistent findings. Herein, we report data on the treatment of children with chronic spontaneous urticaria (CSU) unresponsive to single doses of second-generation H(1)-antihistamines in whom an increase in antihistamine was performed without improvement and with a high prevalence of adverse events. Thus, it appears that well-controlled, well-designed clinical trials are needed to clarify which nonsedating antihistamines should be used, in what dose, and for how long in patients not responding to the standard treatment, despite the improvement in health care that guidelines help to incorporate. Furthermore, a critical use o...

Visión integral de los mecanismos de hipersensibilidad (Dra. Gloria Gil y Dr. Ricardo Cardona)

Comparison and interpretability of the available urticaria activity scores. Authors: Hawro T1, Ohanyan T1, Schoepke N1, Metz M1, Peveling-Oberhag A2, Staubach P2, Maurer M1, Weller K1. 1 Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany. 2 Department of Dermatology, University Medical Center Mainz, Mainz, Germany. Abstract:  The urticaria activity score (UAS) is the gold standard for assessing disease activity in patients with chronic spontaneous urticaria (CSU). Two different versions, the UAS7 and UAS7TD , are currently used in clinical trials and routine care. To compare both versions and to obtain data on their interpretability, 130 CSU patients applied both versions and globally rated their disease activity as none, mild, moderate, or severe. UAS7 and UAS7TD values correlated strongly (r = .90, P < .001). Interquartile ranges for UAS7 and UAS7TD values for mild, moderate, and severe CSU were 11...

Biologic Agents for the Treatment of Chronic Rhinosinusitis With Nasal Polyps. Authors: Kartush AG1, Schumacher JK2, Shah R1, Patadia MO1 1 Department of Otolaryngology, Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois. 2 Department of Internal Medicine. Affiliate clinician: Loyola University Medical Center, Maywood, Illinois. Abstract:  BACKGROUND: Chronic rhinosinusitis with nasal polyposis is a complex inflammatory disorder, which is often recalcitrant to medical and surgical management. Recently, biologic agents have been studied as an adjunct treatment for this patient population. OBJECTIVE: The purpose of this study is to examine the role of biologic agents for chronic rhinosinusitis patients by reviewing literature and clinical trials. METHODS: A comprehensive review of literature and clinical trials-both recently completed and ongoing-was undertaken to examine up-to-date evidence of current biologic therapy and its role in chroni...

Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research Authors: Chehade M1, Jones SM2, Pesek RD2, Burks AW3, Vickery BP3, Wood RA4, Leung DYM5, Furuta GT6, Fleischer DM6, Henning AK7, Dawson P7, Lindblad RW7, Sicherer SH8, Abonia JP9, Sherrill JD9, Sampson HA8, Rothenberg ME9 . 1 Division of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: mirna.chehade@mssm.edu. 2 Division of Pediatric Allergy and Immunology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark. 3 Division of Pediatric Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC. 4 Division of Pediatric Allergy and Immunology, Johns Hopkins University Medical Center, Baltimore, Md. 5 Division of Pediatric Allergy and Clinical Immunology, National Jewish Health, Denver, Colo. 6 Department of...

Reacciones transfusionales (Dra. July Ospina)

Evaluation and Management of Penicillin Allergy: A Review. Authors: Shenoy ES1,2,3, Macy E4, Rowe T5, Blumenthal KG1,6,7. 1 Harvard Medical School, Boston, Massachusetts. 2 Infection Control Unit, Massachusetts General Hospital, Boston. 3 Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston. 4 Department of Allergy, Southern California Permanente Medical Group, San Diego Medical Center. 5 General Internal Medicine and Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 6 Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston. 7 Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital, Boston. Abstract: IMPORTANCE: β-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics that incr...