ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Peanut allergy diagnosis moving from basic to more elegant testing Autor: Dr. Steven Fuentes 

Equipo de protección personal y COVID-19. New England Journal of Medicine 

COVID-19: risk for cytokine targeting in chronic inflammatory diseases? Authors: Schett G1,2, Sticherling M3,4, Neurath MF3,5. Abstract COVID-19, caused by the SARS-CoV-2 virus, has become pandemic. With sharply rising infection rates, patient groups characterized by an enhanced infection risk will be challenged by the virus. In this context, patients with chronic immune-mediated inflammatory diseases are of particular interest, as these diseases are characterized by an intrinsic immune dysfunction leading to inflammation that may enhance risk for severe infection. DOI:   10.1038/s41577-020-0312-7

Opioid Hypersensitivity: Predictors of Allergy and Role of Drug Provocation Testing Authors: Philip H Li  1 , Kok Loong Ue  2 , Annette Wagner  3 , Ryszard Rutkowski  4 , Krzysztof Rutkowski  5 Abstract Background: True IgE-mediated hypersensitivity to opioids is rare and many reactions are due to direct mast cell degranulation. Opioid drug provocation testing (DPT) is the gold standard for diagnosis but is underutilized. Objective: The objective of this study was to evaluate the clinical characteristics and predictors of opioid hypersensitivity, as well as outcomes of opioid DPT. Methods: Patients referred for opioid DPT over the past 9 years were studied. Patient characteristics, indications for opioid use, symptoms of index reaction, and outcomes of DPT were analyzed. Association analysis was performed to study variables associated with a diagnosis of opioid hypersensitivity. Results: Of the total of 98 patients referred with suspected opioid hyp...

Prurito crónico Dr. Steven Fuentes 

Risk Factors for Hen's Egg Allergy in Europe: EuroPrevall Birth Cohort Authors: Kate E.C. Grimshaw, PhD Graham Roberts, MD  Anna Selby, BM E.N. Clare Mills, PhD Thomas Keil, MD Kirsten Beyer, MD Abstract Background Hen's egg is one of the commonest causes of food allergy, but there are little data on its risk factors. Objective To assess the risk factors, particularly eczema, for hen's egg allergy in the EuroPrevall birth cohort. Methods In the pan-European EuroPrevall birth cohort, questionnaires were undertaken at 12 and 24 months or when parents reported symptoms. Children with suspected egg allergy were invited for skin prick testing, specific IgE assessment, and double-blind, placebo-controlled food challenge (DBPCFC) as indicated. Each egg allergy case (positive DBPCFC or egg-induced anaphylaxis) was allocated up to 2 age- and country-matched controls. Results A total of 12,049 infants were recruited into the EuroPrevall birth cohort, and 9,336 (...

Adverse reactions during procedures hypersensitivity to contrast agents and dyes Authors: Christine Schönmann, MD, Knut Brockow, MD  Abstract Objective This review provides an overview of the literature on hypersensitivity reactions during procedures to commonly used contrast agents and dyes. A synthesis of current knowledge on clinical symptoms, epidemiology and risk factors, pathomechanism, and management of hypersensitivity reactions to these substances is presented. Data Sources A literature search was conducted through Medline. Included were peer-reviewed articles written in English between 2000 and 2019. Study Selections Relevant clinical studies, experimental studies, and review articles have been selected. Additionally, case reports have been included if they carried significant information about rare clinical forms of hypersensitivity reactions, disease mechanisms, or therapy. Results An allergological workup is only indicated for patients with...