ALERGOLOGÍA PARA MÉDICOS Y PACIENTES 2021

Prostaglandin D2 receptor antagonists in allergic disorders: safety, efficacy, and future perspectives. Authors: Marone G1,2, Galdiero MR3,4, Pecoraro A3,4, Pucino V5, Criscuolo G3,4, Triassi M1, Varricchi G3,4. 1 a Department of Public Health , University of Naples Federico II , Naples , Italy. 2 b Monaldi Hospital Pharmacy , Naples , Italy. 3 c Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI) , University of Naples Federico II , Naples , Italy. 4 d WAO Center of Excellence , Naples , Italy. 5 e William Harvey Research Institute, Barts and The London School of Medicine &Dentistry , Queen Mary University of London , London , UK. Abstract: Prostaglandin D2 (PGD2) is a major cyclooxygenase mediator that is synthesized by activated human mast cells and other immune cells. The biological effects of PGD2 are mediated by D-prostanoid (DP1), DP2 (CRTH2) and thromboxane prostanoid (TP) receptors that are expressed on s...

Reacciones adversas a aditivos Dr. Luis Carlos Santamaría (Diciembre de 2018)

Thyroid Autoimmunity and Autoimmunity in Chronic Spontaneous Urticaria Linked to Disease Severity, Therapeutic Response, and Time to Remission in Patients with Chronic Spontaneous Urticaria. Authors:  Chanprapaph K, Iamsumang W, Wattanakrai P, Vachiramon V .  Division of Dermatology, Department of Internal Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Abstract:  BACKGROUND: Chronic spontaneous urticaria (CSU) is autoimmune in nature and associated with thyroid autoimmunity (TA), but evidence on autoimmunity in relation to CSU progression and prognosis is limited. We evaluated whether TA and autoimmunity in CSU are correlated with disease severity, therapeutic response, and time to remission and establish an association between CSU characteristics linked to thyroid autoantibody. METHODS: Medical records of patients diagnosed with urticaria attending outpatient dermatology clinic at a university-based hospital from 2013 to 2017 were ...

Unproven Diagnostic Tests for Adverse Reactions to Foods Authors: John M. Kelso , Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, Calif. Abstract: Patients often seek opinions from allergists regarding unconventional testing for adverse reactions to foods. These tests include flow cytometry to measure the change in white blood cell volumes after incubation with foods, measurement of serum IgG or IgG4 antibodies directed against foods, intradermal provocation-neutralization with food allergens, hair analysis, electrodermal testing, and applied kinesiology. In some cases, although the laboratory methods may be valid, there are no studies showing correlation with disease. In other cases, blinded, controlled studies have shown a lack of reproducibility and a lack of correlation with disease. Most of the tests lack biologic plausibility. By understanding the methodology of these tests and the lack of evidence supporting their utility, allergists can ...

"Doctor, I have a Sulfa Allergy": Clarifying the Myths of Cross-Reactivity. Authors: Shah TJ1, Moshirfar M2,3,4, Hoopes PC Sr5. 1 University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA. 2 John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA. cornea2020@me.com. 3 HDR Research Center, Hoopes Vision, Draper, UT, USA. cornea2020@me.com. 4 Utah Lions Eye Bank, Murray, UT, USA. cornea2020@me.com. 5 HDR Research Center, Hoopes Vision, Draper, UT, USA. Abstract: Our purpose is to present an evidence-based approach, directed primarily towards eye-care specialists, clarifying whether certain drugs should or should not be used in patients with sulfonamide allergy. We conducted a literature search using PubMed to identify the risk of ophthalmic-specific drugs in patients with a self-reported sulfonamide allergy. MeSH key words included "sulfonamide" and "hyperse...

Fisiopatología del asma Dra. Catalina López (Diciembre de 2018)

Long-term prophylaxis therapy in patients with hereditary angioedema with C1 inhibitor deficiency. Authors: Craig T1, Busse P2, Gower RG3, Johnston DT4, Kashkin JM5, Li HH6, Lumry WR7, Riedl MA8, Soteres D9. 1 Department of Medicine and Pediatrics, Penn State Hershey Allergy, Asthma, and Immunology, Hershey, Pennsylvania. Electronic address: tcraig@pennstatehealth.psu.edu. 2 Icahn School of Medicine at Mount Sinai, New York, New York. 3 Marycliff Clinical Research, Spokane, Washington. 4 Asthma & Allergy Specialists, Charlotte, North Carolina. 5 Jay M Kashkin, MD Allergy, Asthma and Immunology, Fair Lawn, New Jersey. 6 Institute for Asthma and Allergy, Chevy Chase, Maryland. 7 Allergy and Asthma Research Associates, Dallas, Texas. 8 University of California, San Diego, La Jolla, California. 9 Asthma and Allergy Associates PC, Colorado Springs, Colorado. Abstract: OBJECTIVE: To review the criteria for long-term prophylaxis therapy in patients with hereditary angi...